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Even More Proof Cancer
Is Caused By Bacteria

Alan Cantwell, MD
From: Alan Cantwell
Date: February 23, 2008 2:46:58 PM PST
To: Greg Blaney
Cc: Trevor Marshall
Subject: Re: "Acne bacteria" (P.acnes) repeatedly found in prostate cancer!! More proof of "cancer bacteria"!!
To Greg Blaney, MD:
Thanks for notifying me regarding this important paper published in the Journal of Clinical Microbiology in Nov, 2007......more proof that "cancer bacteria" are involved in cancer -- and particularly in prostate cancer -- now if only we could get pathologists to see these bacteria in acid-fast stained sections of prostate ca -- as noted by me in my partner's tissue sections taken from his prostate cancer when his prostate gland was removed in 2004 - and pictured below in the paper published in the Journal of Independent Medical Research (www.joimr.org) in 2004.
As you note -- from abstracts you attached below, this is NOT the first time Propioniobacterium acnes has been associated with prostate cancer......it amazes me that this research is largely ignored by urologists (and also by the media) -- like Helicobacter pyloris in stomach ulcers was ignored for decades by physicians.
With prostate cancer being an older man's worst nightmare -- one would expect greater interest in this!
Best regards,
On Feb 23, 2008, at 9:10 AM, Greg Blaney wrote:
1: J Clin Microbiol. 2007 Nov;45(11):3721-8. Epub 2007 Sep 19. Links
Direct visualization of Propionibacterium acnes in prostate tissue by multicolor fluorescent in situ hybridization assay.
Alexeyev OA, Marklund I, Shannon B, Golovleva I, Olsson J, Andersson C, Eriksson I, Cohen R, Elgh F.
Department of Pathology, Umeå University, S-90185, Umeå, Sweden. oleg.alexeyev@medbio.umu.se
Prostate tissues from patients with prostate cancer and benign prostatic hyperplasia (BPH) frequently contain histological inflammation, and a proportion of these patients show evidence of Propionibacterium acnes infection in the prostate gland. We developed a multicolor fluorescent in situ hybridization (FISH) assay targeting P. acnes 23S rRNA along with a 14-kb region of the P. acnes genome. This assay was used to analyze prostate tissues from patients with prostate cancer and BPH. P. acnes infection of the prostate gland was demonstrated in prostatic tissue in 5 of 10 randomly selected prostate cancer patients.
FISH analysis and confocal laser microscopy imaging revealed intracellular localization and stromal biofilm-like aggregates as common forms of P. acnes infection in prostate tissues from both prostate cancer and BPH patients. A sequential analysis of prostate tissue from individual patients suggested that P. acnes can persist for up to 6 years in the prostate gland. These results indicate that P. acnes can establish a persistent infection in the prostate gland. Further study is needed to clarify the link between this bacterium and prostatic inflammation which may contribute to the development of BPH and prostate cancer.
PMID: 17881550 [PubMed - indexed for MEDLINE]
Acid-Fast Bacteria In-Vivo in Prostate Cancer and the Connection between Prostate Cancer, Other Cancers, and the Kaposi's Sarcoma Virus
Author: Alan R Cantwell, Jr., M.D.
Los Angeles, California,
contact email: alancantwell@sbc global.net
Paper Type: Review
Please cite as: Cantwell AR Jr. Acid-Fast Bacteria In-Vivo in Prostate Cancer and the Connection between Prostate Cancer, Other Cancers, and the Kaposi's Sarcoma Virus. JOIMR 2004;2(3):1
Published: 28 May 2004
(C) 2004, by Alan Cantwell, Jr. M.D.
Bacteria in the form of previously described "cancer microbes" were identified in a Fite (acid-fast)-stained histopathologic tissue section from a case of prostate adenocarcinoma in a 68 year- old, HIV-negative Italian-American man with a concomitant history of a solitary skin lesion of classic Kaposi's sarcoma. The pleomorphic bacteria observed in vivo are consistent with so-called cancer-associated bacteria previously described in breast cancer, Kaposi's sarcoma, and other forms of cancer, by various investigators over the past century. The proposed microbiology of cancer is discussed, as well as the new finding of the Kaposi's sarcoma virus (human herpes virus-8) in the blood of up to 40% of patients with prostate cancer. Further studies of acid-fast bacteria in vivo and the KS virus in prostate cancer are sorely needed to further determine the possible role of these infectious agents in this common cancer of men.
1: J Urol. 2000 Oct;164(4):1221-8.
Related Articles, Links
Bacterial dna sequences in prostate tissue from patients with prostate cancer and chronic prostatitis.
Krieger JN, Riley DE, Vesella RL, Miner DC, Ross SO, Lange PH.
Department of Urology, University of Washington, School of Medicine, Seattle, Washington, USA.
PURPOSE: Although bacterial genetic material has been detected in prostate tissue from patients with various disorders, the prevalence of these organisms is unknown. We tested the hypothesis that bacterial detection rates differ between patients with prostate cancer and those with the chronic prostatitis/pelvic pain syndrome. MATERIALS AND METHODS: Sterile prostate biopsies were obtained during radical retropubic prostatectomy from 107 patients with prostate cancer and using a perineal approach from 170 with the chronic prostatitis/pelvic pain syndrome. Numerous controls were also evaluated. Bacterial ribosomal encoding DNA (165 rDNA) sequences were detected using a polymerase chain reaction assay. Selected positives were cloned, sequenced and compared with DNA databases. RESULTS: Bacterial DNA sequences were detected in 21 (19. 6%) of 107 patients with prostate cancer compared to 79 (46.4%) of 170 with chronic prostatitis (p <0.0001). These bacteria included urogenital pathogens, other described microorganisms and bacteria not reported previously. CONCLUSIONS: Bacterial DNA sequences may be identified in prostate tissue from many patients. Bacterial detection rates in prostate tissue appear to differ among populations, with higher rates among patients with the chronic prostatitis/pelvic pain syndrome than among those with prostate cancer. Future studies of the role of various bacteria in the prostate may provide insight into the pathophysiology of prostate disease.
1: J Urol. 2005 Jun;173(6):1969-74.
Related Articles, Links
Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution?
Cohen RJ, Shannon BA, McNeal JE, Shannon T, Garrett KL.
Uropath Pty Ltd, Perth, Western Australia. ronnie@uropath.com.au
PURPOSE: Inflammation is commonly observed in the prostate gland and has been implicated in the development of prostate cancer. The etiology of prostatic inflammation is unknown. However, the involvement of a carcinogenic infectious agent has been suggested. MATERIALS AND METHODS: Prostatic tissue from 34 consecutive patients with prostate cancer was cultured to detect the presence of bacterial agents. Prostatic inflammation was assessed by histological examination of wholemount tissue sections. RESULTS: The predominant microorganism detected was Propionibacterium acnes, found in 35% of prostate samples. A significantly higher degree of prostatic inflammation was observed in cases culture positive for P. acnes (p =0.007). P. acnes was separated into 3 groups based on cell surface properties, phenotype and genetic grouping. All skin control isolates were classified as group 1 whereas most prostatic isolates were classified as groups 2 and 3. CONCLUSIONS: P. acnes has been isolated from prostatic tissues in men who underwent radical prostatectomy for localized cancer and has been shown to be positively associated with prostatic inflammation. This inflammation may then be linked to the evolution of carcinoma. Furthermore, organisms infecting these patients with prostate cancer differ genetically and phenotypically from the commonly identified cutaneous P. acnes isolates, suggesting that specific subtypes may be involved in development of prostatic inflammation.
1: Future Oncol. 2006 Apr;2(2):225-32. Links
Links between Propionibacterium acnes and prostate cancer.
Shannon BA, Garrett KL, Cohen RJ.
Tissugen Pty Ltd, Perth, Western Australia.
Incidental foci of prostate cancer are found at autopsy in 30% of men in their third decade, and by their eighth decade more than 75% have histological evidence of cancer. This unprecedented cancer prevalence points to a ubiquitous causative agent or perhaps an interaction between multiple common carcinogenic cofactors. We propose that one of these carcinogens is Propionibacterium acnes. Several characteristics of prostate cancer suggest the involvement of an infectious agent and we provide evidence that P. acnes is an excellent candidate. We have cultured P. acnes from a substantial proportion of prostate glands containing cancer and shown a significant positive association with prostatic inflammation. P. acnes is well suited to cause persistent, low-grade infection involving a marked inflammatory response and the P. acnes subtypes most frequently associated with prostate cancer become highly prevalent in the urinary tract of males following puberty.
PMID: 16563091 [PubMed - indexed for MEDLINE]
1: Res Microbiol. 2007 May;158(4):386-92. Epub 2007 Feb 21. Links
Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors.
Coenye T, Peeters E, Nelis HJ.
Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium. tom.coenye@ugent.be
Propionibacterium acnes plays an important role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles. Recently, it was suggested that P. acnes cells residing within the follicles grow as a biofilm. In the present study, we tested the biofilm-forming ability of several P. acnes strains in a microtiter plate model. We also evaluated the resistance of biofilm-grown P. acnes towards antimicrobial agents commonly used in the treatment of acne and the production of putative virulence factors. Our results indicate that P. acnes can form biofilms in vitro. The results also show that sessile P. acnes cells are more resistant to various commonly used antimicrobial agents than planktonic cells. In addition, sessile cells produce more extracellular lipases as well as significant amounts of the quorum-sensing molecule autoinducer-2.
PMID: 17399956 [PubMed - indexed for MEDLINE]

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