Mad Cow, Scrapie, And CJD -
Some Interesting References
From Bob Lee
We are told that the reason there is an increase in Cruetzfeldt-Jakob's disease worldwide is because cows were fed infected sheep brains. While this is certainly possible, this sounds like the initial explanation for origin of AIDS, i.e., someone ate an infected monkey. There is a possible alternative explanation for those who would look. It would be an interesting study for someone to examine spongioform encephalopathy studies in depth between the years 1960 and 1975 in the context of the current Mad-Cow/Cruetzfeldt-Jakob epidemic with particular interest in appearance of bovine spongioform encephalitis.
Here are some interesting references concerning historic study of scrapie:
Scrapie, the disease in sheep related to Mad Cow disease and Creutzfeldt-Jakob disease was under study in 1966-67 (as well as before):
e.g., Alper, T.; Haig, D. A. and Clarke, M. C. (1966) "The exceptionally small size of the scrapie agent." Biochem. Biophys. Res. Commun. 022:278
e.g., Alper, T.; Cramp, W. A.; Haig, D. A. and Clarke, M. C. (1967) "Does the agent of Scrapie replicate without nucleic acid?" Nature (London) 214:764
This was in the context of interest in brain-attacking agents in 1966-67:
e.g., Gajdusek, D. C.; Gibbs, C. J. and Alpers, M. (1966) "Experimental transmission of a kuru-like syndrome to chimpanzees." Nature (London) 209:794-796
Rats were experimentally infected with scrapie in 1967:
e.g., Pattison, L. H. and Jones, K. M. (1967b) "The astrocytic reaction in experimental scrapie in the rat." Res. Vet. Sci. 08:160-165
In 1968 we see:
e.g., Matthews, W. S. (1968) "Cruetzfeldt-Jakob disease (spongiform encephalopathy): Transmission to the chimpanzee." Science 161:388-389
Primates were experimentally infected with scrapie in 1972:
e.g., Gibbs, C. J., Jr. and Gajdusek., D. C. (1972) "Transmission of Scrapie to the Cynomolgus monkey (Macaca fascicularis)." Nature (London) 236:73-74
And additional studies of interest were conducted:
e.g., Hooks, J.; Gibbs, C. J.; Chopra, H. C.; Lewis, M. and Gajdusek, D. C. (1972) "Spontaneous transformation of human brain cells grown in vitro and description of associated virus particles." Science 176:1420-1422
e.g., Hooks, J. J.; Gibbs, C. J. Jr.; Chou, S.; Howk, R.; Lewis, M. and Gadjusek, D. C. (1973) "Isolation of a new simian foamy virus from a spider monkey brain culture." Infect. Immun. 08:803-813
Take care and thanks!
Bob Lee


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