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- We are told that the reason there is an increase in Cruetzfeldt-Jakob's
disease worldwide is because cows were fed infected sheep brains. While
this is certainly possible, this sounds like the initial explanation for
origin of AIDS, i.e., someone ate an infected monkey. There is a possible
alternative explanation for those who would look. It would be an interesting
study for someone to examine spongioform encephalopathy studies in depth
between the years 1960 and 1975 in the context of the current Mad-Cow/Cruetzfeldt-Jakob
epidemic with particular interest in appearance of bovine spongioform encephalitis.
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- Here are some interesting references concerning historic
study of scrapie:
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- Scrapie, the disease in sheep related to Mad Cow disease
and Creutzfeldt-Jakob disease was under study in 1966-67 (as well as before):
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- e.g., Alper, T.; Haig, D. A. and Clarke, M. C. (1966)
"The exceptionally small size of the scrapie agent." Biochem.
Biophys. Res. Commun. 022:278
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- e.g., Alper, T.; Cramp, W. A.; Haig, D. A. and Clarke,
M. C. (1967) "Does the agent of Scrapie replicate without nucleic
acid?" Nature (London) 214:764
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- This was in the context of interest in brain-attacking
agents in 1966-67:
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- e.g., Gajdusek, D. C.; Gibbs, C. J. and Alpers, M. (1966)
"Experimental transmission of a kuru-like syndrome to chimpanzees."
Nature (London) 209:794-796
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- Rats were experimentally infected with scrapie in 1967:
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- e.g., Pattison, L. H. and Jones, K. M. (1967b) "The
astrocytic reaction in experimental scrapie in the rat." Res. Vet.
Sci. 08:160-165
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- In 1968 we see:
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- e.g., Matthews, W. S. (1968) "Cruetzfeldt-Jakob
disease (spongiform encephalopathy): Transmission to the chimpanzee."
Science 161:388-389
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- Primates were experimentally infected with scrapie in
1972:
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- e.g., Gibbs, C. J., Jr. and Gajdusek., D. C. (1972) "Transmission
of Scrapie to the Cynomolgus monkey (Macaca fascicularis)." Nature
(London) 236:73-74
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- And additional studies of interest were conducted:
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- e.g., Hooks, J.; Gibbs, C. J.; Chopra, H. C.; Lewis,
M. and Gajdusek, D. C. (1972) "Spontaneous transformation of human
brain cells grown in vitro and description of associated virus particles."
Science 176:1420-1422
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- e.g., Hooks, J. J.; Gibbs, C. J. Jr.; Chou, S.; Howk,
R.; Lewis, M. and Gadjusek, D. C. (1973) "Isolation of a new simian
foamy virus from a spider monkey brain culture." Infect. Immun. 08:803-813
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- http://www.bhc.edu/EastCampus/leeb/aids/index.html.
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- Take care and thanks!
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- Bob Lee
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