- PROVIDENCE, R.I. -- As brain development goes, "bad" or "inappropriate"
experiences are worse than no experiences at all, according to a study
in the Jan. 28, 1999, issue of Nature. The study shows that the loss of
connections between neurons in the brain is not the result of inactivity,
as previously thought, but a consequence of activity that is inappropriate.
- Experiences during early postnatal life
sculpt the connections between neurons in the brain. Some connections,
initially formed early in fetal development, are retained and made stronger,
while others are weakened and eventually lost. This refinement of connections
is responsible for the acquisition of brain function during infancy. While
the mechanisms of experience-dependent brain modification normally are
responsible for the improvement of function during development, in some
clinical conditions they can actually lead to a loss of function.
- For example, a loss of function during
infant development can result when one eye is deprived of normal visual
experience, as can occur with a cataract. As a consequence of this deprivation,
connections serving the eye in the brain are weakened to the point that
the eye becomes blind. The blindness is a result of a change in the brain,
so it persists even when the cataract is removed.
- For some time, the weakening between
connections in the brain following "one eye" deprivation was
considered a consequence of inactivity in the eye. In fact, the eye remains
active even with the eyelids closed. The difference between the open and
closed eye is the pattern of activity. The activity generated by a seeing
eye is like the signals of a well-tuned radio station. The activity generated
by an eye with a cataract, or with the lids closed, is more like static.
- Researchers in the Howard Hughes Medical
Institute and Department of Neuroscience at Brown University tested the
validity of a theory developed by Nobel Laureate Leon Cooper and associates
at Brown. The theory suggested "static" in the deprived eye actually
caused connections to become weaker.
- Graduate student Cindi Rittenhouse and
professors Harel Shouval, Michael Paradiso and Mark Bear tested that theory
in a group of test animals. Half of the animals received a drug that blocked
all electrical activity in one eye; the other half simply had their eyelids
- In line with the theory, but in contrast
to the conventional view, the researchers found that the weakening between
connections caused by eyelid closure was far more severe than the weakening
caused by blocking all activity in the deprived eye. The finding suggests
that it might be possible to "freeze" connections in the brain
by blocking activity.
- "This result is counterintuitive.
You would expect that complete absence of activity would be most severe,"
said Bear. "This static appears to help drive changes in the same
process used to sculpt connections.
- "It is important to understand the
mechanism by which connections are weakened - not only because such understanding
may yield insight into ways that at least one type of blindness can be
avoided, but also because this is a fundamental part of normal brain development."