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GMO-DNA Vaccines And Cytokine Storms
By Richard Brown
Of particular note for anyone concerned about autism are parental claims that the vaccines led immediately to intense reactions in the children - screaming, severe diarrhea, seizures, etc.
Work by Russell Blaylock, a neurosurgeon investigating vaccination damage, points to cytokine reactivity as the inherent danger in all vaccines and the responses he lists dovetail with autism (and other disorders).
"The flu virus is supposed to cause a "cytokine storm," and this inflammatory overreaction is what causes the damage, not the virus itself. This is interesting because all vaccines also cause a cytokine storm, one that can last for decades. This is why vaccines are linked to sudden death, joint pains, depression, weakness and fatigue, mental cloudiness, seizures, neurological disorders, and autoimmune diseases. (No one seems to be concerned about vaccine-caused cytokine storms, which are, in fact, immunoexcitotoxicity.)"
And yet developers of GMO-DNA vaccines applaud as a special advantage, that GMO-DNA vaccines induce large cytokine reactions.
Cytotoxic T-cell responses
One of the greatest advantages of DNA vaccines is that they are able to induce cytotoxic T lymphocytes (CTL) without the inherent risk associated with live vaccines [creating the disease itself]. CTL responses can be raised against immunodominant and immunorecessive CTL epitopes,[31] as well as subdominant CTL epitopes,[21] in a manner which appears to mimic natural infection. This may prove to be a useful tool in assessing CTL epitopes of an antigen, and their role in providing immunity.
Cytotoxic T-cells recognise small peptides (8-10 amino acids) complexed to MHC class I molecules (Restifo et al., 1995). These peptides are derived from endogenous cytosolic proteins which are degraded and delivered to the nascent MHC class I molecule within the endoplasmic reticulum (ER).[32] Targeting gene products directly to the ER (by the addition of an amino-terminal insertion sequence) should thus enhance CTL responses. This has been successfully demonstrated using recombinant vaccinia viruses expressing influenzaproteins,[32] but the principle should be applicable to DNA vaccines too. Targeting antigens for intracellular degradation (and thus entry into the MHC class I pathway) by the addition ofubiquitin signal sequences, or mutation of other signal sequences, has also been shown to be effective at increasing CTL responses.[16]
CTL responses can also be enhanced by co-inoculation with co-stimulatory molecules such as B7-1 or B7-2 for DNA vaccines against influenza nucleoprotein,[31][33] or GM-CSF for DNA vaccines against the murine malaria model P. yoelii.[34] Co-inoculation with plasmids encoding co-stimulatory molecules IL-12 and TCA3 have also been shown to increase CTL activity against HIV-1 and influenza nucleoprotein antigens.[33][35]
"Cytotoxic T cells usually kill virally infected cells. However, they can also be stimulated to secrete antiviral cytokines such as INF- and TNF-, which don't kill the cell but place severe limitations on viral infection by down-regulating the expression of viral components.[45]
"In general, co-administration of pro-inflammatory agents (such as various interleukins, tumor necrosis factor, and GM-CSF) plus TH2 inducing cytokines increase antibody responses, whereas pro-inflammatory agents and TH1 inducing cytokines decrease humoral responses and increase cytotoxic responses (which is more important in viral protection, for example). Co-stimulatory molecules like B7-1, B7-2 and CD40L are also sometimes used.
"... the potential toxicity of prolonged cytokine expression has not been established, and in many commercially important animal species, cytokine genes still need to be identified and isolated. In addition, various plasmid encoded cytokines modulate the immune system differently according to the time of delivery.
"Plasmid DNA itself appears to have an adjuvant effect on the immune system.  Bacterially derived DNA has been found to trigger innate immune defence mechanisms, the activation of dendritic cells, and the production of TH1 cytokines. 
"DNA-primed immune responses can be boosted by the administration of recombinant protein or recombinant poxviruses.
As they stress the advantages of boosting cytokine production in multiple areas, they admit not knowing THE most relevant thing they must - the potential toxicity of what they are doing.
Worse, any trust in their knowing the basic science behind what they doing falls away in reading that "the actual mechanism of DNA uptake is not known."  But once must realize that GM0-DNA vaccines are entirely about DNA uptake.  This leaves their complex, optimistic "scientific" assertions above under a cloud since they admit not knowing the fundamental mechanism of what they are attempting to achieve.  They have gotten as far as genetically engineered DNA which they want to insert into the body, to be taken up by the body.  But they have no idea how that would occur.  And all the methods for their introduction of the genetically engineered DNA below show how crude their methods are to get that GMO material into the cells, including a gun.  (They use a "gene gun" in the same primitive way to genetically engineer seeds, creating mutations.)
It is important to realize that GMO-DNA vaccines arose from a failed genetic experiment to begin with, and GMOs for food are associated with diseases while the biotech developers said they were perfectly safe.  The companies involved have been lying, about safety, about great humanitarian plans to feed the poor of the world.  With GMO-DNA vaccines, the promises are for health for the poor of the world, but health is drastically declining, even in the US, and that decline may be related to vaccines.
If one looks at the report of the basic methods of insertion, one sees constant unknowns, along with dangers.  Repeatedly they say that the "response may not be the response required."  And if this is an industry article promoting GMO-DNA vaccines, one would reasonably expect that dangers listed here are being minimized.
Advantages and disadvantages of commonly used DNA vaccine delivery methods
Method of Delivery Advantage Disadvantage Intramuscular or Intradermal injection
No special delivery mechanism
Permanent or semi-permanent expression
pDNA spreads rapidly throughout the body
Inefficient site for uptake due to morphology of muscle tissue
Relatively large amounts of DNA used
Th1 response may not be the response required  [What response might it be?  Might it be dangerous, bizarre, lethal?]
Gene Gun
DNA bombarded directly into cells
Small amounts DNA
Th2 response may not be the response required  [What response might it be?  Might it be dangerous, bizarre, lethal?]
Requires inert particles as carrier
Jet injection
No particles required
DNA can be delivered to cells mm to cm below skin surface
Significant shearing of DNA after high-pressure expulsion [What do that mean about what gets into the body?  Is it dangerous, bizarre, lethal?]
10-fold lower expression, and lower immune response
Requires large amounts of DNA (up to 300 g)
Liposome-mediated delivery
High levels of immune response can be generated
Can increase transfection of intravenously delivered pDNA
Intravenously delivered liposome-DNA complexes can potentially transfect all tissues
Intranasally delivered liposome-DNA complexes can result in expression in distal mucosa as well as nasal muscosa and the generation of IgA antibodies
Ineffectiveness in serum
Risk of disease or immune reactions
However they attempt to get this material into the cells of people and have DNA "uptake," and beyond their unknowns from it, what is known is that they are shooting  recombinant poxvirus, Mason-Pfizer monkey virus, SV40, cytomegalovirus (CMV), synthetic introns, adenovirus, cationic liposome-DNA preparations, biodegradablemicrospheres, attenuated Shigella or Listeria vectors for oral administration to the intestinal mucosa, recombinant adenovirus vectors, recombinant vaccinia viruses expressing influenza proteins - mixtures of genetically engineered viruses and animal poxes.
Advantages And Disadvantages Of Nucleic Acid-Based Immunization
Advantages Disadvantages
Subunit vaccination with no risk for infection[1]
Antigen presentation by both MHC class I and class II molecules[1]
Able to polarise T-cell help toward type 1 or type 2[1]
Immune response focused only on antigen of interest
Ease of development and production[1]
Stability of vaccine for storage and shipping
Obviates need for peptide synthesis, expression and purification of recombinant proteins and the use of toxic adjuvants[8]
Long-term persistence of immunogen[2]
In vivo expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications[2]
Limited to protein immunogens (not useful for non-protein based antigens such as bacterial polysaccharides)
Risk of affecting genes controlling cell growth
Possibility of inducing antibody production against DNA
Possibility of tolerance to the antigen (protein) produced
Potential for atypical processing of bacterial and parasite proteins[1]
The table mention cost effectiveness, along with ease of development, production, shipping and storage for the manufacturer along with promises of what the vaccines can do, but the dangers are immense.  Three stand out.
Risk of affecting genes controlling cell growth
Possibility of inducing antibody production against DNA
Potential for atypical processing of bacterial and parasite proteins
In the list of disadvantages (which they do not call dangers), they mention immune reactions.  That would include the cytokine storm they are designing for maximum impact, an immune reaction that itself can lead to "sudden death, joint pains, depression, weakness and fatigue, mental cloudiness, seizures, neurological disorders, and autoimmune diseases."  (Blaylock)
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