- First large-scale skin microbes inventory charts types,
locales of bacteria
- PHILADELPHIA - Most people think of rain forests as hot
spots for biological diversity, but new research suggests that belly buttons
are also rich ecosystems. That's one finding from the first attempt to
take a large-scale inventory of microbes on human skin.
- In recent years scientists have come to appreciate that
people are super organisms, composed not just of human tissue, but also
of microbes galore. Human skin is covered by a wide variety of bacteria,
viruses, fungi and mites, says Elizabeth Grice, a genomics researcher
at the National Human Genome Research Institute in Bethesda, Md. Most
of the time, people and their microbes live in harmony, but people with
skin conditions such as eczema often also struggle with skin infections.
- "The skin is two square meters of ecosystem,"
Grice said November 13 in Philadelphia at a meeting of the American Society
of Human Genetics.
- Grice presented work she and her colleagues have done
to catalog the diversity of bacteria living on human skin. The findings
could help doctors and scientists better understand why some people develop
skin conditions such as eczema and psoriasis while other people with similar
genetic backgrounds do not.
- "We know there is a genetic component" to eczema,
says Kimberly Chapman, a clinical geneticist at the Children's Hospital
of Philadelphia who was not involved in the research. Some people with
eczema have a defect in filaggrin, a protein that helps form the skin's
protective barrier. But not everyone who has filaggrin variations associated
with eczema will get the skin condition. The new inventory of bacteria
could help researchers determine whether people with eczema have an unbalanced
immune response to bacteria living on their skin, says Chapman.
- In the new study, dermatologists collected skin scrapings
from 21 places on the bodies of 10 healthy volunteers. The participants
were asked to wash only with Dove soap for a week, because the soap is
mild and doesn't contain antibacterial chemicals. For 24 hours before
the samples were collected the volunteers weren't allowed to shower or
wash their hands.
- Grice and her colleagues examined genetic diversity in
the 16S ribosomal RNA gene in bacteria in the samples. The gene encodes
an RNA used in the protein-building machinery in bacterial cells. Some
parts of the gene contain many variations that scientists can use to
distinguish one type of bacteria from another. This technique has been
used to sample bacteria living in a wide variety of ecosystems, including
oceans, human and mouse intestines, and even on shower curtains and toothbrushes.
- Some parts of the body contain an abundance of bacterial
species. Among the most diverse spots were the belly button, inner forearm,
buttocks, the skin between the fingers and the gluteal crease (also known
as the plumber's crack). Other body parts have a relative dearth of bacterial
diversity. Among the skin's diversity, cold spots are the greasy spot
just behind the ear, the crease on the side of the nose, the toe webs
and the sternum.
- In some spots on some volunteers the researchers found
up to 300 different species of bacteria, Grice says. Other areas contained
as few as three different types of bacteria. The amount of diversity
varied greatly not only from body part to body part but also from person
- Oily spots tended to have an abundance of Propionibacteria,
which can break down fatty acids in the oil for food. Corynebacteria,
Staphlococcus and Propionibacteria were often found on moist skin, while
dry skin, like the heel, had more Staphylococcus. There are many varieties
of Staphylococcus bacteria present on the skin, not just Staphylococcus
aureus, a type of bacteria often linked to skin infections.
- The researchers plan to test the healthy volunteers again
six months after collecting the first samples to see whether bacteria
on the skin change over time. Grice and her colleagues are also recruiting
volunteers with eczema to see if people with skin conditions have different
types of bacteria on their skin.
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