- What does this tell me? 1. Prion infection can take
place via urine and blood. 2. If this happens with scrapie, it more then
likely occurs with bse, CWD, CJD, etc, etc.
-
- Patty
-
-
- Urinary Excretion And Blood Level Of Prions In Scrapie-Infected
Hamsters
-
- Yuichi Murayama, Miyako Yoshioka, Hiroyuki Okada, Masuhiro
Takata, Takashi Yokoyama and Shirou Mohri
-
- http://vir.sgmjournals.org/cgi/content/abstract/88/10/2890
-
- J Gen Virol 88 (2007), 2890-2898; DOI 10.1099/vir.0.82786-0
-
- Prion Disease Research Center, National Institute of
Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan
-
- Correspondence Yuichi Murayama ymura@affrc.go.jp
-
- Prions, infectious agents causing transmissible spongiform
encephalopathy (TSE), are composed primarily of the pathogenic form (PrPSc)
of the host-encoded prion protein. Although very low levels of infectivity
have been detected in urine from scrapie-infected rodents, no reports of
urinary PrPSc have been substantiated. Studies on the dynamics of urinary
PrPSc during infection are needed to ensure the safety of urine-derived
biopharmaceuticals and to assess the possible horizontal transmission of
prion diseases. Using the protein misfolding cyclic amplification technique,
a time-course study of urinary excretion and blood levels of PrPSc was
performed in Sc237-infected hamsters and a high rate of PrPSc excretion
was found during the terminal stage of the disease. Following oral administration,
PrPSc was present in all buffy coat samples examined; it was also present
in most of the plasma samples obtained from hamsters in the symptomatic
stage. PrPSc was excreted in urine for a few days after oral administration;
subsequently, urinary PrPSc was not detected until the terminal disease
stage. These results represent the first biochemical detection of PrPSc
in urine from TSE-infected animals.
-
-
- Patricia A. Doyle DVM, PhD Bus Admin, Tropical Agricultural Economics
Univ of West Indies
- Please visit my "Emerging Diseases" message board at:
- http://www.emergingdisease.org/phpbb/index.php Also my new website:
- http://drpdoyle.tripod.com/
- Zhan le Devlesa tai sastimasa
- Go with God and in Good Health
-
-
|
