- Source - Journal of Virology
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- (The following information is taken from the abstract
of a paper entitled "Transmission and Adaptation of Chronic Wasting
Disease to Hamsters and Transgenic Mice: Evidence for Strains," by
Gregory J. Raymond and 9 others, published in the April 2007 issue of the
Journal of Virology p. 4305-4314, Vol. 81, No. 8 http://jvi.asm.org/cgi/content/abstract/81/8/4305.
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- The authors are at the Laboratory of Persistent Viral
Diseases, Rocky Mountain Veterinary Branch, NIAID, NIH, Rocky Mountain
Laboratories, Hamilton, Montana 59840, Department of Veterinary Sciences,
University of Wyoming, Laramie, Wyoming 82070, and the Colorado Division
of Wildlife, Wildlife Research Center, Fort Collins, Colorado 80526-20974.
- Mod.CP)
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- In vitro screening using the cell-free prion protein
conversion system [which assays sensitivity to proteinase K digestion]
indicated that certain rodents may be susceptible to chronic wasting disease
(CWD). Therefore, CWD isolates from mule deer, white-tailed deer, and elk
were inoculated intracerebrally into various rodent species to assess the
rodents' susceptibility and to develop new rodent models of CWD.
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- The species inoculated were Syrian golden, Djungarian,
Chinese, Siberian, and Armenian hamsters, transgenic mice expressing the
Syrian golden hamster prion protein, and RML Swiss and C57BL10 wild-type
mice.
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- The transgenic mice and the Syrian golden, Chinese, Siberian,
and Armenian hamsters had limited susceptibility to certain of the CWD
inocula, as evidenced by incomplete attack rates and long incubation periods.
For serial passages of CWD isolates in Syrian golden hamsters, incubation
periods rapidly stabilized, with isolates having either short (85 to 89
days) or long (408 to 544 days) mean incubation periods and distinct neuropathological
patterns. In contrast, wild-type mouse strains and Djungarian hamsters
were not susceptible to CWD.
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- These results show that CWD can be transmitted and adapted
to some species of rodents and suggest that the cervid-derived CWD inocula
may have contained or diverged into at least 2 distinct transmissible spongiform
encephalopathy (TSE) strains.
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- These rodent-adapted CWD models may be useful in comparative
studies of TSE strains in vivo as well as for testing potential anti-TSE
therapeutic agents.
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- http://jvi.asm.org/cgi/content/abstract/81/8/4305
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- Reported by Joseph P. Dudley, Ph.D
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- Patricia A. Doyle DVM, PhD
- Bus Admin, Tropical Agricultural Economics
- Univ of West Indies
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board at:
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