- Chem. Res. Toxicol., ASAP Article 10.1021/tx700026r S0893-228x(70)00026-7
- Web Release Date: April 14, 2007
- Copyright © 2007 American Chemical Society
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- Particulate Depleted Uranium Is Cytotoxic and Clastogenic
to Human Lung Cells
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- Sandra S. Wise, W. Douglas Thompson, AbouEl-Makarim
Aboueissa, Michael D. Mason, and John Pierce Wise, Sr.
- http://pubs.acs.org/cgi-bin/sample.cgi/crtoec/asap/html/tx700026r.html#tx700026rAF1
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- Wise Laboratory of Environmental and Genetic Toxicology,
University of Southern Maine, 96 Falmouth Street, Portland, Maine 04104-9300,
Maine Center for Toxicology and Environmental Health, University of Southern
Maine, 96 Falmouth Street, Portland, Maine 04104-9300, Department of Applied
Medical Science and Department of Mathematics and Statistics, University
of Southern Maine, 96 Falmouth Street, Portland, Maine 04104-9300, and
Institute for Molecular Biophysics, Department of Chemical and Biological
Engineering, University of Maine, Orono, Maine 04469
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- Received January 18, 2007
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- Abstract
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- Depleted uranium (DU) is commonly used in military armor
and munitions, and thus, exposure of soldiers and non-combatants is potentially
frequent and widespread. DU is considered a suspected human carcinogen,
affecting the bronchial cells of the lung. However, few investigations
have studied DU in human bronchial cells. Accordingly, we determined the
cytotoxicity and clastogenicity of both particulate (water-insoluble) and
soluble DU in human bronchial fibroblasts (WTHBF-6 cells). We used uranium
trioxide (UO3) and uranyl acetate (UA) as prototypical particulate and
soluble DU salts, respectively. After a 24 h exposure, both UO3 and UA
induced concentration-dependent cytotoxicity in WTHBF-6 cells. Specifically,
0.1, 0.5, 1, and 5 g/cm2 UO3 induced 99, 57, 32, and 1% relative
survival, respectively. Similarly, 100, 200, 400, and 800 M UA induced
98, 92, 70, and 56% relative survival, respectively. When treated with
chronic exposure, up to 72 h, of either UO3 or UA, there was an increased
degree of cytotoxicity.
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- For full paper:
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- http://pubs.acs.org/cgi-bin/sample.cgi/crtoec/asap/html/tx700026r.html
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