- WASHINGTON (Reuters) - A
compound used by blueberries and grapes to fight off fungal infections
could help lower cholesterol, U.S. researchers reported on Tuesday.
- The compound, called pterostilbene, also helps regulate
blood sugar and might help fight type-2 diabetes, the researchers told
a meeting of the American Chemical Society in Philadelphia.
- The finding adds to a growing list of reasons to eat
colorful fruit, especially blueberries, which are rich in compounds known
as antioxidants. These molecules battle cell and DNA damage involved in
cancer, heart disease, diabetes and perhaps also brain degeneration.
- "We are excited to learn that blueberries, which
are already known to be rich in healthy compounds, may also be a potent
weapon in the battle against obesity and heart disease, which are leading
killers in the U.S.," Agnes Rimando of the U.S. Department of Agriculture
in Oxford, Mississippi, said in a statement.
- Rimando's team had previously found pterostilbene in
grapes. It is similar to a better-known antioxidant in grapes -- resveratrol.
- They studied pterostilbene in rat liver cells, soaking
them in four compounds found in blueberries including pterostilbene and
resveratrol. Pterostilbene was the best at activating the PPAR-alpha receptor,
a protein involved in lowering cholesterol and other blood fats.
- In fact, they told the meeting, pterostilbene worked
as well as the commercial drug ciprofibrate -- but it worked more accurately.
It was so specific that it could have fewer side-effects than the drug,
- It is impossible to know yet if simply eating blueberries
will lower cholesterol, Rimando said. But a range of health expert groups,
including the federal government, advise eating as many as 10 servings
of fruits and vegetables a day and blueberries are highly recommended.
- Pterostilbene and resveratrol are related chemicals belonging
to a group of compounds called phytoalexins. Plants produce them in response
to stresses such as fungal infection and ultraviolet light.
- Pterostilbene may also be a promising compound to develop
into a natural-based fungicide, Rimando said.
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