- Helllo Jeff: Yes, now I remember. It was Dr. Shope's
group that was innoculating human volunteers with the new Japanese Encehpalitis/poxivirus
(probably vaccinia) recombinent at Plum Island. Jan. 1999 the research
below is dated. Therefore, the experiment probably took place during 1998
(second half) and in plenty of time to spread WNV. If you remember the
NY 99 is not a simple WNV. It was Kunjn/Japanese Encephalitis and other
viruses.
-
- Dr. Shope, however, is no longer with us, therefore we
cannot ask him about the research or the various Japanese Encephalitis
group of viruses in the vaccine soup.
-
- Patty
-
-
- http://www.nalusda.gov/ttic/tektran/data/000009/05/0000090536.html
-
- INDUCTION OF JAPANESE ENCEPHALITIS VIRUS-SPECIFIC CYTOTOXIC
T
- LYMPHOCYTES IN HUMAN BY POXVIRUS-BASED JE VACCINE CANDIDATES
-
- Author(s):
-
- KONISHI EIJI
- KURANE ICHIRO
- MASON PETER W
- SHOPE ROBERT E
- KANESA-THASAN NIRANJAN
- SMUCNY JOHN J
- HOKE CHARLES H
- ENNIS FRANCIS A
-
-
- Interpretive Summary:
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- Japanese encephalitis (JE) is a mosquito-borne viral
disease that infects pigs, horses, and humans in many areas of the Far
East and Southeast Asia. Japanese encephalitis virus (JEV) infection of
pregnant swine can cause abortion, and many of the successfully delivered
offspring suffer irreversible brain damage. JEV infections of humans or
horses can result in a severe brain infection known as encephalitis. Current
vaccines for JE consist of chemically inactivated viruses prepared from
JEV-infected suckling mice. Preparation of these vaccines is dangerous
and time consuming. In an attempt to develop new vaccines, we have been
engineered and tested genetically engineered poxviruses that encode a some
of the protein immunogens of JEV. These poxviruses have been shown to be
safe and effective vaccines for JE in mice and swine. The current work
describes the further characterization of these recombinant poxviruses.
Specifically, we have demonstrated that these viruses can be safely administered
to human volunteers, and that the vaccinees produced immune responses,
including antibodies and cytotoxic (killer) T- lymphocytes (cells) that
are capable of destroying JEV-infected cells. However, immune responses
were reduced in vaccinees who had a history of vaccination against smallpox.
-
-
- Keywords:
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- virology aphthovirus disease recombinant dna receptor
-
-
- Contact:
-
- P O BOX 848
- GREENPORT LI
- ORIENT POINT
- NY 11944
- FAX: (516)323-2507
- Email: PeterMas@ASRR.ARSUSDA.GOV
-
-
- Approved Date: 1999-01-14
-
-
- TEKTRAN
- United States Department of Agriculture
- Agricultural Research Service
-
-
- Updated: 1999-01-16
- Patricia A. Doyle, PhD
- Please visit my "Emerging Diseases" message
board at:
- http://www.clickitnews.com/ubbthreads/postlist.php?Cat=&Board=emergingdiseas
- es
- Zhan le Devlesa tai sastimasa
- Go with God and in Good Health
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