Brief Aspartame Review -
Formaldehyde Toxicity

From Rich Murray
brief aspartame review: formaldehyde toxicity: Murray 9.11.3 rmforall
Rich Murray, MA Room For All
1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-986-9103
[NutraSweet, Equal, Canderel, Benevia, E951]
aspartame review: methanol, formaldehyde, formic acid toxicity:
Murray 9.5.3 rmforall
formaldehyde from methanol in aspartame: Murray: 12.9.2 rmforall
aspartame & formaldehyde toxicity: Murray 9.9.3 rmforall
EU votes 440 to 20 to approve sucralose, limit cyclamates & reevaluate
aspartame & stevia: Murray 4.12.3 rmforall
Mark Gold exhaustively critiques European Commission Scientific
Committee on Food re aspartame (12.4.2): 59 pages, 230 references
aspartame toxicity coverup increases danger of corporate meltdown:
Michael C. Carakostas of Coca-Cola: Murray 8.11.3 rmforall
The International Society of Regulatory Toxicology and Pharmacology
Carakostas, Michael C., DVM, PhD
Director/Scientific & Regulatory Affairs
The Coca-Cola Company PO Drawer 1734 Atlanta, GA 30301
T. 404/676-4234 F. 404/676-7166 E-mail: [photo]
Aspartame: The world agrees it's safe By Michael Carakostas, DVM, PhD
Director, Scientific and Regulatory Affairs, Coca-Cola
It is commendable that Carakostas mentions the core problem, albeit disparagingly: "During digestion, aspartame yields a very small amount of methanol-- as do many other food substances. The body converts this methanol to formaldehyde, which is instantly converted to formate. Formate is quickly eliminated as carbon dioxide and water."
Plenty of evidence in the mainstream scientific literature since 1973 shows that as much as 30% of the formaldehyde is retained in the body as toxic, cumulative adducts to the DNA, RNA, and proteins in all cells and tissues, leading to pointed reports by informed doctors and experts. Clearly, there are no safe levels for chronic, low-level formaldehyde exposure. If just 10% of the methanol from six cans of diet soda is retained in the body as toxic products of formaldehyde and formic acid, that is sixty times the EPA limit for allowable formaldehyde from daily drinking water.
President Bush & formaldehyde (aspartame) toxicity: Ramazzini Foundation
carcinogenicity results Dec 2002: Soffritti: Murray 8.3.3 rmforall
p. 88 "The sweetening agent aspartame hydrolyzes in the gastrointestinal
tract to become free methyl alcohol, which is metabolized in the liver
to formaldehyde, formic acid, and CO2. (11)" Medinsky MA & Dorman DC.
1994; Assessing risks of low-level methanol exposure. CIIT Act. 14: 1-7.
Ann N Y Acad Sci. 2002 Dec; 982: 87-105.
Results of long-term experimental studies on the carcinogenicity of
formaldehyde and acetaldehyde in rats.
Soffritti M, Belpoggi F, Lambertin L, Lauriola M, Padovani M, Maltoni C.
Cancer Research Center, European Ramazzini Foundation for Oncology
and Environmental Sciences, Bologna, Italy.
"Formaldehyde and acetaldehyde were found to produce an increase in total malignant tumors in the treated groups and showed specific carcinogenic effects on various organs and tissues. PMID: 12562630"
It is certain that high levels of aspartame use, above 2 liters daily for months and years, must lead to chronic formaldehyde-formic acid toxicity, since 11% of aspartame (1,120 mg in 2L diet soda, 5.6 12-oz cans) is 123 mg methanol (wood alcohol), immediately released into the body after drinking (unlike the large levels of methanol locked up in molecules inside many fruits), then quickly transformed into formaldehyde, which in turn becomes formic acid, both of which in time are partially eliminated as carbon dioxide and water.
However, about 30% of the methanol remains in the body as cumulative durable toxic metabolites of formaldehyde and formic acid-- 37 mg daily, a gram every month. [J. Nutrition 1973 Oct; 103(10): 1454-1459. Metabolism of aspartame in monkeys. Oppermann JA, Muldoon E, Ranney RE.] If 10% of the methanol is retained as formaldehyde, that would give 12 mg daily formaldehyde accumulation, about 60 times more than the 0.2 mg from 10% retention of the 2 mg EPA daily limit for formaldehyde in water.
Many scientific studies and case histories report: * headaches
* many body and joint pains (or burning, tingling, tremors, twitching,
spasms, cramps, stiffness, numbness, difficulty swallowing)
* fever, fatigue, swollen glands * "mind fog", "feel unreal", poor memory,
confusion, anxiety, irritability, depression, mania, insomnia, dizziness,
slurred speech, sexual problems, poor vision, hearing (deafness, tinnitus),
or taste * red face, itching, rashes, hair loss, burning eyes or throat,
dry eyes or mouth, mouth sores, burning tongue * obesity, bloating,
edema, anorexia, poor appetite or excessive hunger or thirst
* breathing problems, shortness of breath * nausea, diarrhea or
constipation * coldness * sweating * racing heart, low or high blood
pressure, erratic blood sugar levels * hypothryroidism or hyperthyroidism
* seizures * birth defects * brain cancers * addiction
* aggrivates diabetes, autism, allergies, ADHD, fibromyalgia, chronic
fatigue syndrome, multiple chemical sensitivity, multiple sclerosis,
and interstitial cystitis (bladder pain).
RTM: Smith, Terpening, Schmidt, Gums:
full text: aspartame, MSG, fibromyalgia 1.17.2 rmforall
Jerry D Smith, Chris M Terpening, Siegfried OF Schmidt, and John G Gums
Siegfried O. Schmidt, MD Asst. Clinical Prof. Relief of Fibromyalgia Symptoms Following Discontinuation of Dietary Excitotoxins. The Annals of Pharmacotherapy 2001; 35(6): 702-706. Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA. CASE SUMMARY: Four patients diagnosed with fibromyalgia syndrome for two to 17 years are described. All had undergone multiple treatment modalities with limited success. All had complete, or nearly complete, resolution of their symptoms within months after eliminating monosodium glutamate (MSG) or MSG plus aspartame from their diet. All patients were women with multiple comorbidities prior to elimination of MSG. All have had recurrence of symptoms whenever MSG is ingested.
aspartame in Merck Maxalt-MLT worsens migraine: Murray 7.16.2 rmforall
Migraine MLT-Down: an unusual presentation of migraine
in patients with aspartame-triggered headaches.
Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901.
[Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame,
while 12 oz diet soda has 200 mg.]
Headache Institute, St. Lukes-Roosevelt Hospital Center, New York, NY
Department of Neurology
Albert Einstein College of Medicine, Bronx, NY
Innovative Medical Research
aspartame puts formaldehyde adducts into tissues, Part 1/2
full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall
Formaldehyde derived from dietary aspartame binds to tissue
components in vivo. Life Sci 1998 Jun 26; 63(5): 337-49.
Maria Alemany, PhD (male)
Confirming evidence and a general theory are given by Pall (2002):
testable theory of MCS type diseases, vicious cycle of nitric oxide &
peroxynitrite: MSG: formaldehyde-methanol-aspartame:
Martin L. Pall: Murray: 12.9.2 rmforall
Functional Therapeutics in Neurodegenerative Disease Part 1/2:
Perlmutter 7.15.99: Murray 1.10.3 rmforall
formaldehyde toxicity: Thrasher & Kilburn: Shaham: EPA: Gold: Murray:
Wilson: CIIN: 12.12.2 rmforall
24 recent formaldehyde toxicity [Comet assay] reports:
Murray 12.31.2 rmforall
genotoxins, Comet assay in mice: Ace-K, stevia fine; aspartame poor;
sucralose, cyclamate, saccharin bad: Y.F. Sasaki Aug 2002:
Murray 1.27.3 rmforall [A detailed look at the data] 5-page review
Roberts HJ Aspartame (NutraSweet) addiction.
Townsend Letter 2000 Jan;
Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416
800-827-7991 561-588-7628 561-547-8008 fax 603-225-2100
Aspartame Toxicity Information Center Mark D. Gold 12 East Side Drive #2-18 Concord, NH 03301
"Scientific Abuse in Aspartame Research" gives 223,000 websites for "aspartame" , with the top
10 listings being anti-aspartame, while finds on 700 MB of posts from 20 years of
Usenet groups, 82,600 posts, the top 10 being anti-aspartame. 35 recent aspartame items from 4500 sources. gives 298,141, the top 7 of 10 being
leading and very well informed volunteer anti-aspartame sites. gives 85,200 websites, top 8 of 10 anti. lists 740 aspartame items. 1026 articles 15820 posts 715 members
Community email addresses
Post message:
List owner:
Shortcut URL to this page:




This Site Served by TheHostPros