- From Peter
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- Hi Jeff,
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- Your article on this page http://www.rense.com/general33/mayvome.htm
says that the cause of sCJD is unknown, but an article in the LANCET clearly
shows there are known statistically correlaterd risk factors - i.e. surgery
and working with manure/blood and bone.
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- 1: Lancet 1999 Feb 27;353(9154):693-7
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- Comment in: Lancet. 1999 Nov 20;354(9192):1823.
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- Surgical treatment and risk of sporadic Creutzfeldt-Jakob
disease: a case-control study.
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- Collins S, Law MG, Fletcher A, Boyd A, Kaldor J, Masters
CL.
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- Australian National Creutzfeldt-Jakob Disease Registry,
Department of Pathology, The University of Melbourne, Parkville, Victoria.
s.collins@pathology.unimelb.edu.au
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- BACKGROUND: Apart from the small number of iatrogenic
and familial cases, the cause of most cases of Creutzfeldt-Jakob disease
(CJD) is not known. We aimed to identify risk factors for sporadic CJD.
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- METHODS: In a case-control study, we compared the medical
history and selected demographic characteristics of 241 definite (neuropathologically
confirmed) and probable (clinically likely) patients with CJD, ascertained
from the Australian National Creutzfeldt-Jakob Disease Registry between
Jan 1, 1970, and October 31, 1997, and of 784 controls, recruited from
the community by random telephone interview in August, 1997. Standard logistic
regression was used for the comparisons.
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- FINDINGS: Surgical procedures were significantly associated
with the development of sporadic CJD. This risk progressively increased
with the number of surgical treatments to a maximum for three procedures
(odds ratio 2.13 [95% Cl 1.34-3.41], p=0.002). There was also a significant
association between risk of CJD and residence or employment on a farm (p<0.001)
or market garden (p=0.002) for longer than 10 years. We found no significant
risk associated with a history of blood transfusion, organ transplantation,
major dental work, or occupation.
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- INTERPRETATION: Our findings accord with the hypothesis
that a range of surgical treatments may serve as unrecognised contamination
events and account for a proportion of cases of sporadic CJD. Possible
biases in different methods and times for the acquisition of data on cases
and controls suggest our findings need to be replicated in independent
studies with community controls.
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- PMID: 10073510 [PubMed - indexed for MEDLINE]
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