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Enhanced Infectious Disease
Surveillance Is Now A Fact

From Patricia Doyle, PhD
dr_p_doyle@hotmail.com
11-7-2

Unquestionably, there are a lot of positive changes taking place...such as those mentioned below. However, what do we do when we recognize that an event has occurred...and we have patients showing up are local hospital ERs with infectious diseases?
 
As was the case in Florida a couple of weeks ago, and in Brooklyn, New York back in July, a total hospital lockdown occurred pending diagnosis of patient smallpox. We were fortunate that the paitents in both of those cases did not have the disease. But what if they had been so infected? How can the flow of paitents with an infectious disease, as well as regular hospital patients, be cared for if a hospital is in lockdown?
 
Clearly, we need to combine the enhanced epidemiological tracking with a plan to treat infectious diseases as well as patients who were victims of chemical or nuclear weapons. My plan to set up "isocenters" really needs to be considered.
 
An Isocenter would be a facility that would treat ONLY victims of infectious diseases, chemical weapons or nuclear radiation. These facilities would be set up throughout the US and then put on sealed standby, ready to take active cases if needed. I suggest that each major city (at minimum) would maintain an activated Isocenter Emergency Department and that dispatchers and first responders would be given a criteria of symptoms that would mandate transport of a patient in a biosafety ambulence to nearest Isocenter which would activate and receive patients. This would ensure that local hospitals would not be locked down and the suspected infectious disease patient would be treated in an isolated, controllable environment.
 
Many towns and cities have existing resources of VA Hospitals, closed military bases as well as real estate (apartment complexes, warehouses etc) that could be set up as an Isocenter. If we begin now, before an event occurs, we can construct such facilities and have them ready when the need arises. I hope that the enhanced epidemiological surveillance will combine with Isocenters (facilities that handle Biolevel 4 pathogen diseases) and will save lives.
 
If you would like further information on my concept of Isocenters or information on staffing infrastructure, please contact me at: dr_p_doyle@msn.com
 
Thank you, Patricia Doyle
 
Health Departments Aim To Spot Bioterror
 
 
From Stephen M. Apatow <s.m.apatow@humanitarian.net> Source: AP [edited] 11-6-02
 
Public health officials have developed an odd interest lately in the mundane and arcane.
 
Epidemiologists are tracking orange juice sales at the local Safeway and poring over school attendance data. They're mapping every case of the sniffles they can find and watching surveillance videos to count how many times people sneeze.
 
The idea is that a sudden spike in everyday aches, pains, sniffles, and coughs could signal the earliest stages of a health commissioner's worst nightmare -- a massive biological attack. So in the last few years, an increasing number of health departments have started collecting electronic data from hospital emergency rooms, pharmacies, and other sources in an effort to gauge the overall level of illness in the population.
 
Epidemiologists call their new strategy syndromic surveillance, because it looks for increases in clusters of symptoms ("syndromes" in medical jargon) rather than particular disease diagnoses. In September 2002, public health officials from around the country met at the New York Academy of Medicine to explore the potential of using syndromic surveillance as part of a bioterror alarm system. The conference was organized by the New York City health department with help from the Centers for Disease Control and funding from the Sloan Foundation.
 
The new disease-tracking approach is also on the agenda at the American Public Health Association annual meeting in Philadelphia 9-13 Nov 2002.
 
Last year's anthrax letter campaign was just "a tragic dry-run," Minnesota state epidemiologist Michael Osterholm told his colleagues on the first morning of the conference. "Do not under any circumstances be surprised when the next shoe drops," Osterholm admonished. "It will drop."
 
And more than a year after the Sept. 11 attacks, the nation remains woefully vulnerable to terrorist attacks of all kinds, a panel on homeland security reported recently.
 
If it were to provide early warning of a bioterror attack, syndromic surveillance might avert massive casualties. Even some of the deadliest bioterror agents -- including anthrax, plague and smallpox -- can be treated successfully if they are diagnosed early enough. But they also progress quickly from mild symptoms to serious illness to death, so hours count.
 
"There is the potential of a huge benefit if we really do get early detection of a large bioterror event out of this," said Farzad Mostashari, an assistant commissioner at the New York City health department.
 
Traditionally, health departments have relied on astute doctors to identify bioterror attacks by diagnosis. That's how last fall's attacks came to light; Dr. Larry M. Bush, a physician at JFK Medical Center in Atlantis, Florida, identified anthrax infection in a supermarket tabloid photo editor.
 
"We don't pretend that the technology can replace man or that this is the answer to everything," said Mostashari.
 
But doctors may not recognize such rare diseases as tularemia, Q fever, or bubonic plague -- all potential bioterror agents. And one diagnosis would not tell public health officials very much about the scope, geographic location, or timing of an attack. So to supplement the eyes and ears of individual physicians, some public health departments now monitor everything from emergency room visits, 911 calls, and doctor visits to school absenteeism and sales of cough syrup.
 
Public health has enjoyed a badly needed cash infusion in the year since the World Trade Center and anthrax attacks. The Centers for Disease Control and Prevention got $1.1 billion from Congress this year to beef up bioterrorism defense. It is hard to say exactly how much of that money is going to surveillance, but many experts believe spending a sizable chunk of it on warning systems would be a good idea.
 
"For a long time it was very hard to get people to listen when you talked about public health surveillance," said Margaret Hamburg, vice president for biological programs at the Nuclear Threat Initiative, a Washington, D.C., think tank. "Surveillance simply was not sexy and it was very poorly understood."
 
Until recently, some researchers were skeptical that anything so apparently trivial as cough syrup sales could indicate a significant jump in illness. But researchers have shown that at least with the annual flu season, there are a wealth of indicators that people are getting sick.
 
Elaine Newton, a graduate student at Carnegie Mellon University, has done studies showing that orange juice and paper tissue sales increase at the onset of flu season. She has also found that Internet consumer health web sites dealing with the flu get more hits a few days before a flu outbreak is officially announced.
 
Now Newton is exploring the seemingly far-fetched idea of using surveillance camera footage of public places to gauge the health of the population, perhaps even by counting coughs and sneezes.
 
Such notions naturally raise the issue of privacy. The current systems do not collect names or other identifying information, but Carnegie Mellon computer scientist Latanya Sweeney said anybody who really wanted to identify a person would probably be able to do so by combining data from the bioterror system with facts culled from voter rolls or some other public database.
 
New York has had a system since 1999. It analyzes information from hospital emergency rooms, the 911 system, and ambulance dispatches for sudden increases. The system also collects sales data from city drugstores and absentee statistics from employers and schools as supplementary information.
 
Since June 2001, Seattle's public health department has analyzed reports from 3 emergency rooms and 11 primary care clinics. The Seattle system also monitors 911 dispatches, which are made available via the Internet by the city's fire department.
 
Baltimore even collects information on dog and cat deaths from the city's animal control department, and keeps track of school absenteeism and over-the-counter cold medicine sales.
 
A system in western Pennsylvania collects information on every patient who passes through the doors of 21 hospital emergency departments. It records the age, gender, home ZIP code, time of admission, and chief complaint of each patient, and looks for sudden increases in respiratory illness and other symptoms that might indicate a bioterror attack. A version of the Pennsylvania system was also set up in Utah for the 2002 Winter Olympics, and has been operating there ever since.
 
Monitoring major public events for bioterrorism has become a challenging subspecialty for designers of these early warning systems. In addition to the 2002 Winter Olympics, systems have been set up for the 1999 World Trade Organization meeting in Seattle, both the Democratic and Republican party conventions in 2000 and the 2001 World Series.
 
In October 2002 the Centers for Disease Control and Prevention awarded a $1.2 million grant to Harvard University researchers to begin developing a national warning system that automatically collects information on the number of patients with flu-like symptoms, strange rashes, and other possible symptoms of bioterrorism.
 
The New York health department knows its surveillance system works because it goes off all the time. A sudden increase in rashes at a particularly busy emergency room is much more likely to be a random uptick than a smallpox attack. A rise in fevers and coughs during November almost certainly means "flu," not "anthrax."
 
For example, New York's system issued an alert the day American Airlines Flight 587 crashed on takeoff from JFK airport, 2 months after the World Trade Center attacks. The 2 hospitals nearest to the crash site were reporting an unusually high number of patients with respiratory problems, a possible indicator of an attack with anthrax or several other bioterror agents. When investigators checked with the hospitals, they discovered that the increase was due to a handful of factors, some related to the plane crash and some incidental. There was one firefighter who had smoke inhalation from responding to the crash, 2 cases of flu, 3 asthma attacks, 2 people complaining of chest pain, and one person who appeared upon examination to be having an anxiety attack.
 
"We didn't really think there was a bioterrorism attack," said Mostashari, who is credited with setting up the New York surveillance system. Even so, he added, every suspicious pattern has to be investigated or the system won't work.
 
"We do need something to give us a sense of the pulse of the city," said Marcelle Layton, an assistant commissioner at the New York Department of Health and Mental Hygiene.
 
For all its sensitivity, New York's system did not detect the anthrax attacks last fall. Layton and her colleagues do not consider that a problem, however, because the system is designed to detect major airborne bioterror attacks. Last year's mail attacks were so limited that only one of the 7 New Yorkers who contracted skin anthrax from contaminated letters even visited an emergency room.
 
[By: Matt Crenson]
 
The following information sources provide additional information on the subject matter:
 
1. CDC:MMWR: September 11, 2002 / 51(Special Issue);13-15 Syndromic Surveillance for Bioterrorism Following the Attacks on the World Trade Center --- New York City, 2001 <http://www.cdc.gov/mmwr/preview/mmwrhtml/mm51SPa5.htm>
 
2. DOD:GEIS: Syndromic Surveillance: A New Way to Track Emerging Infectious Diseases <http://www.geis.ha.osd.mil/GEIS/SurveillanceActivities/ESSENCE/ESSENCE.asp>
 
-- Stephen M. Apatow Humanitarian Resource Institute Biodefense Reference Library <http://www.humanitarian.net/biodefense> <s.m.apatow@humanitarian.net>
 
[ProMED-mail has covered 2 of the newer syndromic surveillance projects in prior postings this year under this same thread (Disease surveillance: enchancement) and subscribers are referred to these posts for detailed coverage of the 2 systems: the RSVP system (Rapid Syndrome Validation Project) and the RODS system (Real-Time Outbreak and Disease Surveillance).
 
This news article gives a nice overview of some of the projects presented at the National Syndromic Surveillance Conference in September 2002. Having attended this conference, one of the messages I walked away with was that at the present "state of the art" of syndromic surveillance, with respect to its value in early detection of an intentional biologic event, we are still very dependent upon the astute clinician(s) evaluating the first patient(s) to get the appropriate diagnostic tests to confirm the responsible organism. The value of the various systems to date has been to identify increases in illness patterns (such as influenza-like-illness) a few weeks before the traditional surveillance systems have (the "pneumonia and influenza" systems) data supporting the existence of an outbreak. The intentional anthrax incident was first identified by an astute clinician in Florida. Several of the cutaneous cases had dates of onset preceding the identification of the systemic anthrax case in Florida, but only after that case was identified was the diagnosis of anthrax considered. The strength of these systems is that they allow for real-time monitoring of the order of magnitude of the problem once identified, and the geographic spread, again, once the illness is identified.
 
Many of the presentations from the National Syndromic Surveillance Conference held at the New York Academy of Medicine are available online. <http://www.nyam.org/events/syndromicconference/agenda.shtml>
 
In addition, as mentioned in the previous posting in this thread, there were several presentations related to enhanced surveillance systems and real-time reporting presented at the International Conference on Emerging Infectious Diseases 2002. Readers are encouraged to view the webcasts of these presentations: <http://www.cdc.gov/iceid/webcast/a-z_topics.htm#surveillance_systems> - Mod.MPP]
 
[see also: Disease surveillance: enhancement (02) 20020708.4696 Disease surveillance: enhancement 20020128.3424 Bioterrorism: WHO guidance 20020126.3401 1998 ---- International health regulations, revisions 19980124.0177] ...........................mpp/pg/mpp
 
 
Patricia A. Doyle, PhD Please visit my "Emerging Diseases" message board at: http://www.clickitnews.com/emergingdiseases/index.shtml Zhan le Devlesa tai sastimasa Go with God and in Good Health





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