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Scientists Discover Way To
Regrow Teeth In Mammals

11-7-2

ALEXANDRIA, Virginia -- The Journal of Dental Research has published the results of the first successful regeneration of teeth. Researchers found that when cells obtained from immature teeth of sixth-month-old pigs were seeded onto biodegradable polymer scaffolds and placed in rat hosts, small, recognizable tooth crowns formed within 30 weeks.
 
As published in the October 2002 issue of the Journal, researchers at The Forsyth Institute are the first to report using dissociated tooth tissues (tooth buds enzymatically digested into single cells) combined with polymer scaffolding (a technique used to form a pattern for human tissues and organs) to regenerate teeth. Researchers from other laboratories had previously used alternative approaches to form partial tooth structures including dentin and pulp, but none had grown complete structures that included enamel.
 
The research also suggests the existence of dental stem cellsówhich could be key to bioengineering human teeth. ìThe ability to identify, isolate, and propagate dental stem cells to use in biological replacement tooth therapy has the potential to revolutionize dentistry,î said Dominick P. DePaola, DDS, PhD, president and chief executive officer of The Forsyth Institute, the independent research organization where the work was conducted. Dr. DePaola is also the Vice-president of the American Association for Dental Research, one of the publishers of the Journal of Dental Research.
 
These recent findings emphasize the importance of dental and oral research, as well as the ongoing need for funding of projects. The research has resulted in coverage by not just the dental press, but also the general media worldwide. According to Mark C. Herzberg, DDS, PhD, Editor of the Journal and professor in the Department of Oral Sciences at the University of Minnesota, ìThe JDR publishes major scientific advances quickly and puts important and reliable information into the hands of the scientific community and the public. The JDR is a highly credible peer-reviewed publication, given the breadth of this recent international media coverage.î
 
The Journal of Dental Research is published jointly by the International Association for Dental Research and the American Association for Dental Research, both based in Alexandria, Virginia. The JDR is the #1 dental journal in the world, with a Scientific Impact Factor of 3.35 (a measurement of its citation in other works) and a circulation of over 6,000.
 
The International Association for Dental Research was established in 1920 to promote research in all aspects of oral and related sciences, to encourage development of improved methods for prevention and treatment of oral and dental diseases, and to facilitate cooperation among investigators and communication of research findings and their implications throughout the world. The IADR, a non-profit organization, has over 11,000 active individual members and over 100 institutional members worldwide.
 
 
 
The American Association for Dental Research (a Division of the International Association for Dental Research) is a non-profit organization with over 6,000 individual members and 100 institutional members within the U.S.
 
Contact Linda Hemphill Linda@iadr.org http://www.iadr.com/press/releases/10302.htm





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