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The Methanol In Aspartame Issue
From Dr. Betty Martini,D.Hum
9-18-10
 
Response to Donna.Griffith-Sackey@foodstandards.gsi.gov.uk
 
Dear Donna,
 
I've reviewed your post to Jim McDonald on the methanol issue, and part of your comment just hits me in the face as being wrong and easily proven.  You say to Jim McDonald:  "You obviously have a different understanding of toxicology from our own experts.  We consider it is one of the general principles of toxicology that if the human body is presented with a specific chemical then, irrespective of the source, it will be metabolised according to a specific route.  This is not something on which we consider there is any need for further study.  Of course the presence of other chemicals than the specific chemical may lead to a different metabolism route.  We have previously supplied you with information on the metabolism of aspartame (9 November 2009), and we have indicated that COT are currently considering aspects of methanol toxicity."
 
This is wrong and can be proven.  If the source of methanol is an orange, it will bind to pectin, and take it safely out of the body.  Also there is ethanol which is the classic antidote to methanol toxicity.  If the source of the methanol is aspartame, its free methanol and converts to formaldehyde.  The Trocho Study proves this as a fact proving the formaldehyde embalms living tissue.  Of course, with the added ingredients of aspartame which are also poisonous it's worse.  You understand about the presence of other chemicals.
 
On May 24, 2006 Reuters published the study that showed artificial sweeteners speed alcohol into blood.  Dr. Chris Rayner and colleagues at Royal Adelaide Hospital studied eight healthy male volunteers. On one day, the subjects consumed an orange-flavored vodka drink made from alcohol and a mixer sweetened with sugar containing 478 calories.  On the second day, the man drink the same amount of alcohol with a diet mixer containing 225 calories.  The peak blood alcohol concentration was significantly higher with the diet drink than with the regular drink.  The blood alcohol concentration was also higher with the artificial sweetener than the sugar sweetened drink.  Blood samples were also taken at 30 minute intervals for three hours.  Obviously in 2006 this was aspartame.
 
The findings have public health significance.  Rayner said.  He recommends that product labeling include information on the intoxicating qualities of artificially sweetened alcoholic drinks.  There could be legal implications for those driving home, as well, he noted.
 
I once sent you case of  Matthew Hobson from Yorkshire.  As he slurred his words from the methanol in aspartame he was thought to be on drugs.
 
 
His own words:
 
"Subject: Accused Of Drug Use By School - Aspartame"
 
Aspartame ruined my relationship with my family and I wasn't trusted at school, now I hate them for what they put me through.   The school decided that sugar soft drinks were bad for the students   health so decided to remove all but the diet products from the cafeteria, I personally enjoy a sugar infused cola that has a taste diet drinks lack, they taste too artificial.
 
I started to drink the diet cola, I had no bad effects for a couple of days.  Then by the next week, half an hour after lunch I would get severe itching in my legs and arms, so much so that it left blood marks in scratch lines across my limbs, I tried so hard not to start scratching as I couldn't stop them for about an hour if I started.
 
To make matters worse I would also slur my speech, still unaware of what was going on. The second week my parents were called in and I was told that I would be under supervision at all times in school and my parents were not going to let me leave the house, they proceed to rip apart my room and have me sleep on the floor in their room.
 
Why? I was being accused of using Crystal Meth !!! I hope you can even imagine how I felt about all this, I huddled up in a corner crying at one point wishing I wasn't born.  I spent lunch in the corner of the staff room with a bag of crisps and my diet coke, again as soon as I left the room for lessons I itched like crazy. I have to miss out some details here because they upset me so much.
 
After being drug tested for a couple of days, police interrogating me, asking me who the dealer was and referring me to a shrink which I saw for another week, all this was going on, my life was so bad I just wanted to die.
 
This is where I met someone I will never forget, The Janitor. He saw me and said "are you alright there son"?  I just started crying, so he took me to the supply room, sat me on a box and I poured out my heart to him, I clicked the ring pull on my drink and took a large gulp, He just stared at the can for what seemed like forever.
 
He snatched it off me, grabbed my shirt and pulled me up to the Headmasters office, he kicked in the door and started screaming at the headmaster. I was all over the place I felt so dizzy, emotional ,tired and out of it and I still didn't really know what the hell was going on. He smashed down the can and the diet coke sprayed all over the Head's desk.
 
I caught bits of the conversation, - "It's the xxxx in these drinks - It doesn't take a genius to work that out for God's sake - Don't you know what's in this." From here on he started on about his daughter having PKU and aspartame, he finished with reminding the head in front of about 20 staff surrounding outside the door where i was now stood, that the school in fact was responsible for my problems by removing sugar drinks from the cafeteria and was liable, and should expect to be sued.
 
He calmed down came out and walked me outside, he gave me his phone to ring my parents who then came to the school. The rest is history!!!  I would like to thank Mark Winslow, the Janitor who actually saved my life, God knows what I would have done if he hadn't stepped in. We did gain a settlement from the school and gave a generous sum to Mark as he did lose his job and was unemployed for a couple of weeks. He and his family now regularly meet up with us in the summer for BBQ's and we couldn't ask for better friends.
 
I hope my experience is of benefit to others, I think my reaction must have been very severe but if it can do that to you then it shouldn't be in our foods. -- Matthew Hobson"
 
 
Now do you want to hear it again from a medical doctor?
 
Dr. James Bowen began slurring his words and was thought to either be on alcohol or drugs.  He was admitted to a mental hospital but in the hospital he was no longer on aspartame and the symptoms disappeared.  He wrote:
 
"I started using Aspartame in April 1983, when the Aspartame Lo Cal Kool Aid was first marketed. In 2 days it gave me a toxic cardiomyopathy so severe I had to then stop swimming. I then immediately lost my balance, so also had to immediately also stop going off the diving board. Deep chemical depression followed, terminating in Lou Gehrig's disease. In just six weeks of use it aged me thirty years! When I stopped using it I had many severe withdrawal symptoms, and was then diagnosed as "Bulbar Palsy."
 
MY RN wife was screaming at me: "Jim get off the Aspartame! It is killing you!" (I was so completely brain washed by Aspartame, that I could not even believe her!
 
Aspartame is very highly crafted poison, cleverly combining about ten different poisons, including :1. phenylalanine isolate poisoning. (Not all alike with dietary sources!),  2. The methyl ester-formaldehyde-formic acid- carbon monoxide toxic axis. 3.Methylated aspartic acid , (An extreme excitotoxin, implemented in many and vast brain damages! Including the common neural degenerative diseases!) 4. Diketopiperazine poisoning: Which the first toxicity studies (at 1/1000 the FDA legally requisite test dosage for only sixty days,) caused the highest incidence of brain tumor in rats that any chemical ever tested at any dosage ever caused.(The first 6 months of Aspartame soft drinks, saw a 10% increase in USA human brain cancers rates, and a 30% jump of our diabetes occurrence rate!)
 
When the FDA first refused licensure for Aspartame they did so, because it rapidly chelates poisonous metals out of containers and then carries them on in a totally absorbable condition, it couldn't be proven safe and triggered brain tumors.  It also triggered many other types of tumors from mammary to testicular. It should be noted that Pepsi and Coke delivery drivers certify that sugar pops never damage their cans, while Aspartame beverages frequently do.)
 
James D. Bowen MD "
 
It ought to be also noted that many consumers who go to Alcohol Anonymous tell me they suggest diet drinks.  Naturally they continue this alcohol content so go from ethanol to methanol in aspartame.  One of these people, Victor, said to me:  "I was trying to clean up my life, went to AA, who told use diet drinks.  All of a sudden my health deteriorated.'
 
You can't disregard the evidence in aspartame being on the market for three decades.  Victims talk about slurring their words and being thought to be on alcohol while they were using aspartame.
 
Back when Monsanto was denying the brain tumor issue in 1999, they said
"It is physiologically impossible for aspartame to cause brain tumors because it never enters the bloodstream and thus cannot travel to essential organs, including the brain." Skip down to where industry's own book is being quoted, corporate sponsored - in fact, this is Ajinomoto.
 
"Page 162: RESULTS: Phenylalanine Moiety: "The pattern of distribution of (U-14CPhe) aspartame following its oral administration was very similar to that of (U-14C) phenylalanine after 0.5, 2.6 and 24 hr and 7 days. Thirty minutes after administration of these compounds, very high levels of radioactivity were observed in the lumen of the stomach and upper small bowel. Significant uptake of radioactivity was observed in the pancreas, gastrointestinal mucosa, hair follicles, salivary gland and liver. Radioactivity was observed in the kidney, adrenal gland, bone marrow, spleen and eye. Some radiolabel was localized to the BRAIN, SPINAL CORD, (emphasis added) heart, thymus, lung and testes. "
 
So you see from their own material is the admission that some radiolabel was localized to the brain, spinal cord, heart, thymus, lung and testes.  It's in the brain, Donna, admitted by Ajinomoto themselves.  You can't say it doesn't happen.  Read on.    Betty
 
Page 30: "After ingestion there is a rapid breakdown and absorption of aspartame within the upper gastrointestinal tract. This results in a prompt rise of the two amino acids in the bloodstream."
 
Page 32: "Influence of Method of Administration" Both phenylalanine and aspartame concentrations in the blood plasma are significantly higher when aspartame is given as a solution rather than in capsule form."
 
Aspartame, Physiology and Biochemistry, Marcel Dekker, Inc., New York, L.D. Stegink and L. J. Filer, Jr., l984 (Pro industry, Significantly Corporate Sponsored!!) Searle was original manufacturer, bought by Monsanto in l985
 
Page 161: TISSUE DISTRIBUTION OF ORALLY ADMINISTERED ISOTOPICALLY LABELED ASPARTAME IN THE RAT Yoshimasa Matsuzawa and Yuichi O'Hara, Life Science Laboratory, Central Research Laboratories, Ajinomoto Company, Inc. Yokohama, Japan
 
Page 162: RESULTS: Phenylalanine Moiety: "The pattern of distribution of (U-14CPhe) aspartame following its oral administration was very similar to that of (U-14C) phenylalanine after 0.5, 2.6 and 24 hr and 7 days. Thirty minutes after administration of these compounds, very high levels of radioactivity were observed in the lumen of the stomach and upper small bowel. Significant uptake of radioactivity was observed in the pancreas, gastrointestinal mucosa, hair follicles, salivary gland and liver. Radioactivity was observed in the kidney, adrenal gland, bone marrow, spleen and eye. Some radiolabel was localized to the BRAIN, SPINAL CORD, (emphasis added) heart, thymus, lung and testes.
 
Aspartame, Physiology and Biochemistry, Marcel Dekker, Inc., New York, L.D. Stegink and L. J. Filer, Jr., l984 (Pro industry, Significantly Corporate Sponsored!!) Searle was original manufacturer, bought by Monsanto in l985  (Monsanto sold to Ajinomoto, Merisant, etc. later).
 
Page 161: TISSUE DISTRIBUTION OF ORALLY ADMINISTERED ISOTOPICALLY LABELED ASPARTAME IN THE RAT Yoshimasa Matsuzawa and Yuichi O'Hara, Life Science Laboratory, Central Research Laboratories, Ajinomoto Company, Inc. Yokohama, Japan
 
Page 162: RESULTS: Phenylalanine Moiety: "The pattern of distribution of (U-14CPhe) aspartame following its oral administration was very similar to that of (U-14C) phenylalanine after 0.5, 2.6 and 24 hr and 7 days. Thirty minutes after administration of these compounds, very high levels of radioactivity were observed in the lumen of the stomach and upper small bowel. Significant uptake of radioactivity was observed in the pancreas, gastrointestinal mucosa, hair follicles, salivary gland and liver. Radioactivity was observed in the kidney, adrenal gland, bone marrow, spleen and eye. Some radiolabel was localized to the BRAIN, SPINAL CORD, (emphasis added) heart, thymus, lung and testes.
 
In real world demographic studies that could be dated from July, l981 when aspartame became commercially available, Dr. Roberts in DOES ASPARTAME CAUSE HUMAN BRAIN CANCER?, Journal of Advancement in Medicine, Volume 4, Number 4, Winter 1991, emphasized the extraordinary rise of primary brain lymphoma in persons who were not immunosuppressed within one or two years after the availability of aspartame products. -- and for which no other reasonable cause could be identified. Primary brain lymphoma had been a rare brain tumor prior to that time; subsequently there was a striking rise of other more common primary brain tumors within several years after the availability of aspartame in soft drinks and other products, beginning July, l983. These data on brain cancer statistics were regarded by the American Cancer Society statisticians as significant, and for which no other cause was apparent. Dr. Roberts report was a milestone publication, presented 15 years after the previous demonstration of high incidence of brain tumors in rats given aspartame. Indeed, these experimental studies were the reason that FDA scientists, consultants for the GAO, and a Public Board of Inquiry had urged the FDA Commissioner NOT TO APPROVE aspartame for human use. Unfortunately, a new FDA Commissioner ignored these warnings. In subsequent letters and books by Dr. Roberts, including a communication published in Lancet, Vol. 349, Feb 1, l997, Roberts reemphasized the matter, and urged the FDA to declare aspartame products an imminent public health threat for their potential carcinogenic, neurologic,psychiatric, metabolic and fetotoxic potential based on a clinical database now exceeding 1300 aspartame reactors.
 
As further refutation of assertions by the manufacturer, and the FDA that there are no evidences for severe neurotoxicity, Dr. Roberts and others have listed and reviewed many reports to the contrary -- with emphasis on corporate - neutral studies involving "real world" products subjected to heat and storage. Even corporate - sponsored studies affirmed the matter. For example, one of 15 pivotal studies submitted to the FDA for approval of aspartame was a "52 Week Oral Toxicity Infant Monkey Study (SC-18862). This study orally dosed aspartame to seven infant Rhesus monkeys in work conducted at the University of Wisconsin Medical Center at Madison. Reported in l972. The study reported "All animals in the medium and high dosage groups exhibited seizure activity. Seizures were observed for the first time following 218 days of treatment. The seizures were of the grand mal type...One monkey, m38 of the high dose group, died after 300 days of treatment. The cause of death was not determined..." The study correlates brain seizures with high amounts of phenylalanine ingested by the monkeys. The study determined: "following the end of the experiment, medium and high dose monkeys were kept under observation for three months. No further convulsions were detected during this period." In other words, once the aspartame was withdrawn from the monkey's diets, the brain seizures ceased. Monsanto spokesperson Dr. Robert Moser has said that aspartame does not enter the blood stream. The data revealed by this "pivotal" study submitted to FDA renders false Moser's assertion that Aspartame does not enter the blood stream. Elevated levels of phenylalanine in the blood of monkeys fed medium and high levels of Aspartame prove that the compound is absorbed into the blood stream. The brain seizures followed. How could FDA claim a "pivotal " study in which all of the medium and high dose monkeys suffer brain seizures, confirm Aspartame's safety for humans?
 
Neurosurgeon Russell Blaylock, M.D. in Excitotoxins: The Taste That Kills explains that for every molecule of aspartame metabolized, a molecule of methanol was released into the blood stream. An EPA assessment of methanol states that methanol "is considered a cumulative poison due to the low rate of excretion once it is absorbed" The absorbed methanol is then slowly converted to formaldehyde by alcohol dehydrogenase in the liver (DHHS 1993a, Liesivuori 1991). The formaldehyde is then converted to formic acid by aldehyde dehydrogenase in the liver, by formaldehyde dehydrogenase in the blood or through the tetrahydrofolic acid dependent, one-carbon pool (Liesivuori 1991). Methanol thus breaks down into formaldehyde and formic acid in the body. Journal of the Diabetic Assoc. of India, A Health Alert, Emerging Facts About Aspartame, Vol. No. 35, No. 4: l995, J. Barua, A. Bal
 
During Congressional Hearings on aspartame there was voluntary submission of Trade Secret Information, Document 31. This had to do with Food and Drug Sweetener Strategy on getting aspartame approved and says in the last paragraph: "With the spoon-for-spoon, we have no way of estimating maximum likely abuse and hence need to utilize data based on almost complete conversion to DKP. If we include this use in the original FAP, we stand a good chance of ending up with nothing in the short run and nothing in the long run whereas the other approach would give us something in the short run and quite likely as much as we would ever get in the long run."...
 
DKP is diketopiperazine and has been implicated in the occurrence of brain tumors. Dr. John Olney, noticed that DKP, when nitrosated in the gut, produced a compound which was similar to N-nitrosourea, a powerful brain tumor causing chemical.
 
What is so serious about this situation is that Searle knew before they marketed aspartame that the phenylalanine would break down to DKP, and they didn't think they could get it approved if the FDA found out. Indeed, rats developed brain tumors in original studies. An FDA toxicologist who tried to stop the approval of aspartame, the late Dr. Adrian Gross, told Congress that because aspartame was capable of producing brain tumors and brain cancer, FDA should not have been able to set an allowable daily intake of the substance at any level. He said at least one of Searle's studies "has established beyond any reasonable doubt that aspartame is capable of inducing brain tumors in experimental animals and that this predisposition of it is extremely of high significance...In view of these indications that the cancer causing potential of aspartame is a matter that had been established way beyond any reasonable doubt, one can ask: What is the reason for the apparent refusal by the FDA to invoke for this food additive the so-called Delaney Amendment to the Food, Drug and Cosmetic Act?" The Delaney Amendment makes it illegal to allow any residues of cancer causing chemicals in foods. The concluding testimony of Dr. Gross will never be forgotten. He asked: "Given the cancer causing potential of aspartame, how would the FDA justify its position that it views a certain amount of aspartame as constituting an allowable daily intake or 'safe" level of it? Is that position in effect not equivalent to setting a 'tolerance' for this food additive and thus a violation of that law? And IF THE FDA ITSELF ELECTS TO VIOLATE THE LAW, WHO IS LEFT TO PROTECT THE HEALTH OF THE PUBLIC?" (Emphasis added). Congressional Record SID835:131 (August 1, l985)
 
In Nov l996 John W. Olney, M.D, reported that brain tumor rates had risen for 17 years with a sudden 10% increase three years after aspartame was introduced. Olney linked aspartame's mutagenicity to the function of aspartate as an excitotoxic neurotransmitter. Dr. Olney appeared on 60 Minutes and with him Dr. Ralph Walton who declared that only NutraSweet funded studies showed safety and that 83 of 90 independent studies show it harmful. This year world famous toxicologist, George Schwartz, M.D., in writing to Monsanto said: "By ignoring the scientific studies which disagree with your position, you are doing a great disservice to consumers. Further, you may have created base for litigation against your company by denying the existing science." (Letter on <http://www.dorway.com>http://www.dorway.com ) Dr. H. J. Roberts has now declared Aspartame Disease to be a world epidemic and is in the process of publishing a 700 page medical text on the world plague.  (Now published - Aspartame Disease: An Ignored Epidemic, 1000 pages on the horrors this addictive, excitoneurotoxic, carcinogenic, genetically engineered drug and adjuvant cause. www.sunsentpress.com )
 
Suggested documents to review:
 
FDA audit, Bressler Report,  CDC Investigation,  Protest of National Soft Drink Association
 
Letters from Dr. Adrian Gross to Senator Metzenbaum
 
Affidavit from N. Vera,translator, that studies were done in South America on humans that showed aspartame triggered brain tumors and seizures, and were never published by Searle.
 
These documents on <http://www.dorway.com>http://www.dorway.com
 
Dr. Betty Martini, D.Hum
Founder, Mission Possible International
9270 River Club Parkway
Duluth, Georgia 30097
770-242-2599
<http://www.dorway.com>http://www.dorway.com, www.mpwhi.com, www.wnho.net
Aspartame Toxicity Center, www.holisticmed.com/aspartame
 
Mission Possible Intl is a worldwide volunteer force alerting consumers aspartame is a neurotoxin.
 
The important thing is in intact human beings who are exposed to this on a sustained level, not just with just a couple of doses or so , its cumulative. (Said by H. J. Roberts, M.D.)
 
_______________________________________________________________________
 
Donna, I've pasted in the rest of the report above.   Ajinomoto put their foot in their mouth.  It's in the blood stream, and you have to accept studies that prove this.  What FSA does is rebut the facts and then when found to be wrong ignores the issue altogether. You can't do that.  I sent you all the data from the experts: http://www.mpwhi.com/statement_for_food_standards_october_2009.htm If experts give documentation that doesn't agree with Food Standards you refuse to comment on it.  Remember that Food Standards was set up to distance itself from industry.  You are using industry propaganda instead of scientific fact.
 
I would suggest that you take another approach, like showing what science has proven, and not use fairy tales from flacks of the aspartame industry.  Here is all the propaganda  from industry rebutted with medical references.   http://www.dorway.com/offasprt.html
 
You must stop ignoring the facts so you can please the aspartame industry.  The idea is to protect the public from this dreadful poison.  Food Standards hasn't done that and because the public has not been protected they have suffered dreadfully,  No telling how many have perished.  Dr. Maria Alemany told me 200 million will perish.   This neurotoxin was controversial from day one, before it was ever marketed through the political chicanery of Don Rumsfeld, and after the FDA tried to have G. D. Searle indicted for fraud and revoked the petition for approval.  Doesn't that tell you something.
 
I never did get an answer back from you about who is preparing these cereal bars in the Hull Study?  Today Proposition 65 in California says nothing can come into the state with methanol or formaldehyde without a cancer warning.  That's how well known is what they cause.  You have the US FDA telling Congress aspartame violates the Delaney Amendment because of the brain cancer.  Then you have not one but two Ramazzini studies proving aspartame is a multipotential carcinogen.  You also have the Oncogene study.  Now what if there is another cancer study on aspartame.  Will you finally warn the public or continue to quote industry propaganda.  Every ingredient is poisonous.  You're talking about an excitotoxin and two neurotoxins breaking down to a brain tumor agent.  It's impossible to take a poison and prove its safe.  You would have to use fraud in science and propaganda.  What do you think the aspartame industry has provided?  Is there any wonder that the FDA tried to get them indicted for fraud under Title 18, Section 1001 of the Criminal Code.
 
 
Sincerely,
Betty
 
Dr. Betty Martini, D.Hum, Founder
Mission Possible International
9270 River Club Parkway
Duluth, Georgia 30097
770 242-2599
www.mpwhi.com, www.dorway.com, www.wnho.net
Aspartame Toxicity Center, www.holisticmed.com/aspartame

 
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