- (Note - The withholding of Mammalian
H5N1 sequences from Indonesia is outrageous. -ed)
-
- The latest cluster in Indonesia again
raises the question of human-to-human (H2H) transmission. As in most familial
clusters, there is a 510 day gap between the disease onset date (April
27) of the index case, and other family members (May 34). In addition,
the family members were at an April 29 BBQ, suggesting they were infected
there by the index case. The number of clusters in Indonesia remains
high. In addition to the familial clusters, there is a geographical
cluster in Bekasi.
-
- These clusters are cause for concern,
as is Indonesia's testing procedures. Samples for testing are collected
at infectious disease hospitals. Thus, milder cases that recover
are not tested for H5N1. Moreover, most tested are first asked about
contact with poultry, thereby limiting testing of patients infected by
mammals, including humans and cats.
-
- Only one human H5N1 HA sequence has been
made public and it has a novel cleavage sit, RESRRKKR. This sequence is
not found in any of the many bird H5N1 sequences released from Indonesia
and it is not in any H5N1 sequence at GenBank.
-
- There are now over 30 confirmed human
cases in Indonesia, and H5N1 has been isolated and sequenced from many.
However, these sequences are being withheld and some comments have suggested
that many of the human sequences have RESRRKKR, suggesting the source of
infection is not avian.
-
- The withholding of these mammalian H5N1
sequences from Indonesia should not be tolerated. The evidence for
H2H in Indonesia continues to increase, as do the number of human sequences
that are being withheld. Below are some of the recent avian HA sequences
made public. None have the RESRRKKR cleavge site found in the Indonesian
cluster from July, 2005.
-
- Recent avian H5N1 sequences from Indonesia:
-
- DQ497642.1 A/chicken/Malang/BBVet-IV/2004(H5N1)
- DQ497643.1 A/chicken/Magetan/BBVW/2005(H5N1)
- DQ497644.1 A/chicken/Ngawi/BPPV4/2004(H5N1)
- DQ497645.1 A/chicken/Pekalongan/BPPV4/2003(H5N1)
- DQ497646.1 A/chicken/Sragen/BPPV4/2003(H5N1)
- DQ497647.1 A/quail/Boyolali/BPPV4/2004(H5N1)
- DQ497648.1 A/chicken/Purworejo/BBVW/2005(H5N1)
- DQ497649.1 A/quail/Yogjakarta/BBVet-IX/2004(H5N1)
- DQ497650.1 A/chicken/Kulon Progo/BBVet-XII-2/2004(H5N1)
- DQ497651.1 A/chicken/Gunung Kidal/BBVW/2005(H5N1)
- DQ497652.1 A/chicken/Kulon Progo/BBVW/2005(H5N1)
- DQ497653.1 A/chicken/Purwakarta/BBVet-IV/2004(H5N1)
- DQ497654.1 A/quail/Tasikmalaya/BPPV4/2004(H5N1
- DQ497655.1 A/chicken/Bangli Bali/BBPV6-1/2004(H5N1)
- DQ497656.1 A/chicken/Bangli Bali/BPPV6-2/2004(H5N1)
- DQ497657.1 A/chicken/Jembrana/BPPV6/2004(H5N1)
- DQ497658.1 A/chicken/Mangarai-NTT/BPPV6/2004(H5N1)
- DQ497659.1 A/duck/Parepare/BBVM/2005(H5N1)
- DQ497660.1 A/chicken/Kupang-2-NTT/BPPV6/2004(H5N1)
- DQ497661.1 A/chicken/Kupang-3-NTT/BPPV6/2004(H5N1)
- DQ497662.1 A/chicken/Kupang-1-NTT/BPPV6/2004(H5N1)
-
- © 2006 Recombinomics. All
rights reserved.
- http://www.recombinomics.com/News/05170604/H5N1_Indonesia_Withheld.html
|
