- WASHINGTON (Reuters) - Women
who have genetic mutations giving them a high risk of breast cancer can
virtually eliminate the risk by having their breasts removed, researchers
reported on Monday.
- The women who opted for double mastectomies reduced their
breast cancer risk by 90 percent, the international team of researchers
- They did not check to see if the women's death rate from
breast cancer was also reduced -- breast cancer is curable -- but said
they assumed this would be the case.
- "Our study shows that bilateral prophylactic mastectomy
markedly reduces the risk of breast cancer in women who are genetically
predisposed to the disease," said Dr. Barbara Weber, a professor of
medicine and genetics at the University of Pennsylvania, who led the study.
- "Women undergoing this procedure should feel confident
that if they choose this risk management option, it will reduce their risk
of breast cancer to almost zero."
- The women in the study had mutations in genes called
BRCA1 and BRCA2, which greatly increase the risk of breast cancer. Some
such women have opted to have mastectomies instead of living with the fear
of breast cancer.
- Writing in the Journal of Clinical Oncology, Weber and
her colleagues said they followed 483 women from 11 sites in the United
States, Canada, United Kingdom and the Netherlands over six years. All
of the women had BRCA mutations and some opted for the mastectomies.
- Breast cancer, which can develop in lymph nodes outside
the breasts, was diagnosed in two of the 105 women who had mastectomies,
or 1.9 percent. But 184 of the 378 women who did not undergo the procedure
developed breast cancer -- or 48 percent.
- Weber said mastectomy should be up to the woman, but
she strongly recommended that women with BRCA1 and BRCA2 mutations should
have their ovaries removed after they finish having children.
- BRCA mutations also raise the risk of ovarian cancer,
a rare but deadly cancer. Unlike breast cancer, it cannot be detected in
- But having the ovaries removed brings on early menopause.
The symptoms of menopause can be treated with hormone replacement therapy,
but in women with their ovaries such therapy raises the risk of heart disease,
stroke and some cancers.
- Weber's team said the overall life expectancy of women
who had their ovaries taken out did not change.
- From Name Withheld
- Dear Jeff,
- With regard to the article on breast amputation as a
cancer preventative, I am appalled that anyone would suggest that amputation
of a part of the body as a means of preventing disease. Whatever happened
to the cornerstone of Hippocratic medicine, namely: "First do no harm."
- There is a very simple method of avoiding breast cancer:
do not wear a bra. This article at: http://www.all-natural.com/bras.html
- describes why studies have shown that women who wear
bras often are more likely than those who don't. The theory is that wearing
tight garments such as the bra compresses the lymphatic system in the chest,
causing disease bearing toxins to accumulate there.
- As for ovarian cancer, it is madness to remove a healthy
organ on the assumption that someday it might become cancerous. Are the
people who came up with this idea going to suggest that men undergo castration
to prevent similar problems? I hope not.