- Enclosed are 2 .pdf file showing SARS E2-spike protein
in a phylogeny with 12 other coronaviruses. The viruses in the phylogeny
include:
-
- VGL2_CVBF E2 glycoprotein precursor (Spike glycoprotein)
(Peplomer protein) [Contains: Spike protein S1 (90B); Spike protein S2
(90A)]
-
- S44241 surface protein - human coronavirus
-
- AAF25499.1 spike glycoprotein [bovine coronavirus]
-
- AAL80031.1 spike glycoprotein [porcine hemagglutinating
encephalomyelitis virus]
-
- AAB30950.1 S=viral surface peplomer {monoclonal antibody
resistant} [murine hepatitis virus MHV, Wb 1, MAR 11F/1, Peptide Mutant,
1235 aa]
-
- VGL2_CVMJH E2 glycoprotein precursor (Spike glycoprotein)
(Peplomer protein) [Contains: Spike protein S1 (90B); Spike protein S2
(90A)]
-
- AAF97738.1 spike protein [rat sialodacryoadenitis coronavirus]
-
- NP_828851.1 putative E2 glycoprotein precursor; putative
spike glycoprotein [SARS coronavirus]
-
- S37664 peplomeric polyprotein precursor - avian infectious
bronchitis virus (strain D1466) (fragment)
-
- AAO34396.1 spike glycoprotein [Avian infectious bronchitis
virus]
-
- S41453 spike protein - canine coronavirus
-
- AAA46905.1 S protein [Porcine respiratory coronavirus]
-
- BAC05493.1 peplomer protein [feline infectious peritonitis
virus]
-
- You will notice in the pictures (the phylogenies) that
SARS E2 protein is not like any other animals' E2 spike protein. It is
not like the other human spike protein compared either. It is its own
"branch" on the coronavirus tree. SARS E2 spike protein appears
related to the avian, dog, cat, pig, and rat coronavirus E2 spike proteins
but is not, apparently, derived from any of these. The common ancestor
of the SARS E2 spike protein also gave rise to the rat sialodacryoadenitis
coronavirus spike protein. It would appear that SARS E2 spike protein
and the avian infectious bronchitis viruses and feline infectious peritonitis
virus and canine cornavirus as well as the porcine respiratory virus were
derived from a common ancestor.
-
- That common ancestor... whatever it is/was... also
gave birth to bovine coronavirus and murine hepatitis virus.
-
- The common ancestor of the common ancestor virus (the
grandparent, if you will)... whatever that one is/was, also seems to have
given birth to porcine hemagglutinating encephalomyelitis virus.
-
- That SARS E2 spike protein does not show a closer relatedness
to the other human coronavirus spike protein is really surprising. SARS
seems to be a real mixture of several different animal coronaviruses --
bird, dog, cat, pig, rat... and is not really closely related to other
human coronaviruses.
-
- But it is infecting humans... and shows no really close
relationship to any other known human coronaviruses. It would appear that
the disease SARS would show itself in serious bronchitis, peritonitis,
and, perhaps, encephalomyelitis.
-
- I selected the SARS E2 spike protein for this analysis
as it is this spike protein that allows the virus to dock with cells and
initiate infection. It is my thought that SARS is an FcgammaR agent as
are some others of the coronavirus family. It is important that this be
determined as it has direct bearing on what type of immunology is occurring
in SARS. If SARS is an FcgammaR agent then it is likely possible that
it is provoking an intense hyperimmune reaction in some people that would
destroy the surfactin in their lungs and cause hypoxia.
-
- Bob Lee
-
- SARSE2phylogeny.pdf
SARSE2phylogenyradial.pdf
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