- Note: this information is copyright 2003 (c) Robert E.
Lee
-
- Note: this information is granted by Robert E. Lee for
display on Jeff Rense's website at http://www.rense.com
-
- Note: copy of this material is granted by Robert E. Lee
with the stipulation that ALL material herein be contained including both
the Lee 2003 copyright and the Jeff Rense website address at http://www.rense.com
-
- Note: Any written reference concerning SARS E2-spike
protein mimicking T-cell Receptor alpha-beta V shall give credit to this
original work.
-
- Note: This information was submitted 5/21/2003. As of
this date no one anywhere in the world has published on this finding to
my knowledge.
-
- Hello, Jeff
- As you know, I have been examining the SARS coronavirus
E2-spike protein in some detail.
- Interestingly, the E2-spike protein appears to be mimicking
T-cell Receptor alpha-beta V chain protein (TCRalpha-betaV) in a region
about residue 680 to residue 1050 as indexed in the SARS E2-spike protein.
The implications of the molecular mimickry of SARS E2-spike protein (which
appears to be using a CD13 pathway to enter cells) is that SARS coronavirus
will initiate a profound hyperimmune disorder (autoimmune disorder) in
some individuals. Individuals who are more likely to have this autoimmune
reaction appears to be people of MHC Class II HLA-DR, -DP, and
-DQ histocompatibility.
-
- It appears likely that SARS E2-spike protein's mimickry
of TCRalpha-betaV is causing an infected person's immune system to respond
to the SARS coronavirus as if the virus proteins are, what are called in
by the molecular biologists/virologists, a "super antigen." This
"super antigen" (mimicking TCRalphabetaV) appears to be deregulating
the infected person's own natural T-cell functioning resulting in, what
appears very like, a "graft-vs-host" disease in the infected
person. The infected person's immune system seems to be responding
to the SARS-coronavirus-mimickry of a foreign (not self) histocompatibility
complex.
-
- These mimicked T-cell Receptor alpha-beta V chain-like
amino acids in SARS coronavirus E2-spike protein appear
to be tricking the infected person's immune system into
thinking that a foreign histocompatibility complex is present and so the
their immune system is activated. As their immune system may be activated
and more of their own cells may be displaying CD13 antigen on
cell surfaces, the result would be greater opportunity for
the virus to spread (as it appears to target CD13 antigen). The more cells
that can be invaded, the greater the degree of virus-induced graft-vs-host
disease.
-
- In short, what appears to be going on in SARS infection
is a virus-induced autoimmune disorder and the body's normal immunological
processes are short-circuited. Persons who are killed by the SARS coronavirus
are, apparently, having a profound immunological reaction to the molecular
mimickry in SARS E2-spike protein which results in a highly active immune
system which gives opportunity for the virus to spread even faster. I have
explained this reaction most simply this way: SARS E2-spike protein mimickry
of T-cell Receptor alpha-beta V chain protein is similar to throwing gasoline
on an open fire... think of SARS E2-spike mimickry of T-cell Receptor alpha
beta V chain as an immune system "accelerant." If the reader
is a molecular biologist, please check the literature on super antigens
and their relationship to TCRalphabetaV and the relationship of this to
MHC Class II HLA-DR and relationship to autoimmune disease and then
examine SARS E2-spike protein amino acids between 700 to 1050 and compare
these amino acids to protein 1BWMA at PubMed Central. I have provided technical
detail below to any scientist with interest.
-
- More work needs to be done, of course, to understand
this virus. Others will need to confirm these observations.
-
- I am providing technical information below.
-
- Thanks, Jeff!
- Bob Lee
-
- Note: this information is copyright 2003 (c) Robert E.
Lee
-
- Note: this information is granted by Robert E. Lee for
display on Jeff Rense's website at http://www.rense.com
-
- Note: copy of this material is granted by Robert E. Lee
with the stipulation that ALL material herein be contained including both
the Lee 2003 copyright and the Jeff Rense website address at http://www.rense.com
- Note: Any written reference concerning SARS E2-spike
protein mimicking T-cell Receptor alpha-beta V shall give credit to this
original work.
-
- Note: This information was submitted 5/21/2003. As of
this date no one anywhere in the world has published on this finding to
my knowledge.
-
- Data .pdf
-
- AAMSAsars1bwma.pdf
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