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PDR Is Clear - Haldol Should
Not Taken With Effexor Or Wellbutrin
From Daniel Fey
danfey@earthlink.net
6-24-1

Jeff,
 
These references are copied directly from the PDR consumer website. IT CLEARLY SAYS THAT HALDOL IS NOT TO BE TAKEN WITH EITHER EFFEXOR OR WELLBUTRIN AT THE END OF THE SECTIONS ON WELLBUTRIN AND EFFEXOR.
 
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WELLBUTRIN

* More common side effects may include: Abdominal pain (Wellbutrin SR), agitation, anxiety (Wellbutrin SR), constipation, dizziness, dry mouth, excessive sweating, headache, loss of appetite (Wellbutrin SR), nausea, palpitations (Wellbutrin SR), vomiting, skin rash, sleep disturbances, sore throat (Wellbutrin SR), tremor

* Other side effects may include: Acne, allergic reactions (severe), bed-wetting, blisters in the mouth and eyes (Stevens-Johnson syndrome), blurred vision, breathing difficulty, chest pain, chills, complete or almost complete loss of movement, confusion, dry skin, episodes of over-activity, elation, or irritability, extreme calmness, fatigue, fever, fluid retention, flu-like symptoms, gum irritation and inflammation, hair color changes, hair loss, hives, impotence, incoordination and clumsiness, indigestion, itching, increased libido, menstrual complaints, mood instability, muscle rigidity, painful ejaculation, painful erection, retarded ejaculation, ringing in the ears, sexual dysfunction, SUICIDAL IDEATION (emphasis added), thirst disturbances, toothache, urinary disturbances, weight gain or loss
 
Why Should This Drug NOT Be Prescribed?
 
Do not take Wellbutrin if you are sensitive to or have ever had an allergic reaction to it.
 
Since Wellbutrin causes seizures in some people, do not take it if you have any type of seizure disorder or if you are taking another medication containing bupropion, such as Zyban, the quit smoking aid.
 
If you have had any kind of heart trouble or liver or kidney disease, be sure your doctor knows about it before you start taking this drug.
 
You should not take Wellbutrin if you currently have, or formerly had, an eating disorder. For some reason, people with a history of anorexia nervosa or bulimia seem to be more likely to experience Wellbutrin-related seizures.
 
Do not take Wellbutrin if, within the past 14 days, you have taken a monoamine oxidase inhibitor (MAO inhibitor) drug, such as the antidepressants Marplan, Nardil or Parnate. This particular drug combination could cause you to experience a sudden, dangerous rise in blood pressure.
 
 
Special Warnings About This Medication
 
If you take Wellbutrin, you may be vulnerable to seizures if your dosage is too high or if you ever suffered brain damage or experienced seizures in the past.
 
Stop taking Wellbutrin and call your doctor immediately if you have difficulty breathing or swallowing; notice swelling in your face, lips, tongue, or throat; develop swollen arms and legs; or break out with itchy eruptions. These are warning signs of a potential severe allergic reaction.
 
The danger of seizures is greater in people addicted to narcotics, cocaine, or stimulants, and in those using over-the-counter stimulants or diet pills. Alcohol abuse or withdrawal also increases the risk, as does the use of other antidepressants or major tranquilizers. The risk is higher, too, if you are taking insulin or oral diabetes medication.
 
Because seizures are possible, if you have been taking Valium or a similar tranquilizer but are ready to stop, taper off gradually rather than quitting abruptly.
 
Since Wellbutrin may impair your coordination or judgment, do not drive or operate dangerous machinery until you find out how the medication affects you.
 
 
Possible Food And Drug Interactions When Taking This Medication
 
Do not drink alcohol while you are taking Wellbutrin; an interaction between alcohol and Wellbutrin could increase the possibility of a seizure.
 
If Wellbutrin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Wellbutrin with the following:
 
Beta-blockers (used for high blood pressure and heart conditions) such as: Inderal, Lopressor, and Tenormin Carbamazepine (Tegretol) Cimetidine (Tagamet) Cyclophosphamide (Cytoxan) Dilantin Heart-stabilizing drugs such as Rythmol and Tambocor Levodopa (Larodopa) Major tranquilizers such as Haldol, Risperdal, Thorazine, and Mellaril MAO inhibitors (such as the antidepressants Parnate and Nardil) Orphenadrine (Norgesic) Other antidepressants such as Elavil, Norpramin, Pamelor, Paxil, Prozac, Tofranil, and Zoloft Phenobarbital Steroid medications such as Prednisone Theophylline (Theo-Dur)
 
 
Overdose Symptoms


* Symptoms of Wellbutrin overdose may include: Hallucinations, heart failure, loss of consciousness, rapid heartbeat, seizures
 
* Symptoms of Wellbutrin SR overdose may include: Blurred vision, confusion, jitteriness, lethargy, light-headedness, nausea, seizures, vomiting
 
* An overdose that involves other drugs in combination with Wellbutrin may also cause these symptoms: Breathing difficulties, coma, fever, rigid muscles, stupor
 
 
********
 
 
EFFEXOR
 
What Side Effects May Occur?
 
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Effexor.

* More common side effects may include:
 
Abdominal pain, abnormal dreams, abnormal ejaculation/orgasm, anxiety, blurred vision, chills, constipation, cough, diarrhea, dizziness, dry mouth, extreme muscle tension, flushing, frequent urination, gas, headache, impotence, inability to sleep, indigestion, loss of appetite, menstrual problems, nausea, nervousness, prickling or burning sensation, rash, runny nose, sleepiness, sweating, tremor, vomiting, weakness, yawning

* Less common side effects may include:
 
Abnormal thinking, abnormal vision, accidental injury, agitation, belching, blood in the urine, bronchitis, bruising, changeable emotions, chest pain, confusion, decreased sex drive, depression, difficult or painful urination, difficulty in breathing, difficulty swallowing, dilated pupils, ear pain, fever, high or low blood pressure, inflammation of the vagina, injury, itching, lack of orgasm, light-headedness on standing up, lockjaw, loss of touch with reality, menstrual problems, migraine headache, neck pain, orgasm disturbance, rapid heartbeat, ringing in the ears, taste changes, twitching, vague feeling of illness, vertigo, weight loss or gain

* Rare side effects may include:
 
Abnormally slow movements, abnormal movements, abnormal sensitivity to sound, abnormal speech, abortion, abuse of alcohol, acne, alcohol intolerance, allergic reaction, anemia, angina pectoris (crushing chest pain), apathy, appendicitis, arthritis, asthma, bad breath, black stools, bleeding gums, blocked intestine, blood clots, blood clots in the lungs, blood disorders, bluish color to the skin, body odor, bone disease and/or pain (including osteoporosis), breast enlargement or swelling, breast pain, brittle nails, bulging eyes, cancerous growth, cataracts, changed sense of smell, chest congestion, cold hands and feet, colitis (inflamed bowel), confusion, conjunctivitis ("pinkeye"), coughing up blood, deafness, delusions, depression, diabetes, double vision, drug withdrawal symptoms, dry eyes, dry skin, ear infection, eczema, enlarged abdomen, enlarged thyroid gland, exaggerated feeling of well-being, excessive hair growth, excessive menstrual flow, eye disorders, eye pain, fainting, fungus infection, gallstones, glaucoma, gout, hair discoloration, hair loss, hallucinations, hangover effect, heart disorders, hemorrhoids, hepatitis, herpes infections, high cholesterol, hives, hostility, hyperventilation (fast, deep breathing), inability to communicate, increased mucus, increased physical activity, increased salivation, increased sensitivity to touch, increased sex drive, inflammation of the stomach, intestines, anus and rectum, gums, tongue, eyelid, or inner ear, intolerance to light, involuntary eye movements, irregular or slow heartbeat, kidney disorders, lack of menstruation, large amounts of urine, laryngitis, loss of consciousness, loss of muscle movement, low or high blood sugar, middle ear infection, mouth fungus, mouth sores, muscle spasms, muscle weakness, nosebleeds, over- and underactive thyroid gland, overdose, paranoia, pelvic pain, pinpoint pupils, "pins and needles" around the mouth, pneumonia, prolonged erection, psoriasis, rectal hemorrhage, reduced menstrual flow, restlessness, secretion of milk, seizures, sensitivity to light, skin disorders, skin eruptions or hemorrhage, skin inflammation, sleep disturbance, soft stools, stiff neck, stomach or peptic ulcer, stroke, stupor, sugar in the urine, swelling due to fluid retention, swollen or discolored tongue, taste loss, temporary failure to breathe, thirst, twisted neck, ulcer, unconsciousness, uncoordinated movements, urgent need to urinate, urination at night, uterine and vaginal hemorrhage, varicose veins, voice changes, vomiting blood, yellowed eyes and skin
 
 
Why Should This Drug Not Be Prescribed?
 
Never take Effexor while taking other drugs known as MAO inhibitors. (See "Most important fact about this drug.") Also avoid this drug if it has ever given you an allergic reaction.
 
 
 
Special Warnings About This Medication
 
Your doctor will prescribe Effexor with caution if you have high blood pressure, heart, liver, or kidney disease or a history of seizures or mania (extreme agitation or excitability). You should discuss all of your medical problems with your doctor before taking Effexor.
 
Antidepressants such as Effexor may cause fluid retention, especially if you are an older adult.
 
Effexor may cause you to feel drowsy or less alert and may affect your judgment. Therefore, avoid driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness until you know how this drug affects you.
 
If you have ever been addicted to drugs, tell your doctor before you start taking Effexor.
 
If you develop a skin rash or hives while taking Effexor, notify your doctor.
 
Do not stop taking the drug without consulting your doctor. If you stop suddenly, you may have withdrawal symptoms, even though this drug does not seem to be habit-forming. Your doctor will have you taper off gradually.
 
The safety and effectiveness of Effexor have not been established in children under 18 years of age.
 
 
Possible Food And Drug Interactions When Taking This Medication
 
Combining Effexor with MAO inhibitors could cause a fatal reaction. (See "Most important fact about this drug.")
 
Although Effexor does not interact with alcohol, the manufacturer recommends avoiding alcohol while taking this medication.
 
If you have high blood pressure or liver disease, or are elderly, check with your doctor before combining Effexor with cimetidine (Tagamet).
 
Effexor does not interact with Lithium or Valium. However, you should consult your doctor before combining Effexor with other drugs that affect the central nervous system, including narcotic painkillers, sleep aids, tranquilizers, antipsychotic medicines such as Haldol, and other antidepressants such as Tofranil.
 
 
*******
 
 
http://www.walnet.org/llf/drugs/haldol.html#start
 
HALDOL (Haloperidol)
 
CATEGORY: ANTIPSYCHOTIC/NEUROLEPTIC DRUG FOR
 
chronic schizophrenia and other psychoses major tranquilizer control of hyperactive behaviour in children
 
 
SHOULD NOT BE USED OR SHOULD BE USED CAREFULLY WHEN THERE IS use of drugs for depression (within 14 days)
 
 
use of tranquilizers, drugs for tension (within 14 days)
use of other antipsychotic/neuroleptic drugs
use of lithium, levodopa
use of sedatives, sleeping pills, pain killers
use of alcohol
use of antacids
alcohol withdrawal
coma (passed out)
severe depression
Parkinson's disease or Parkinson's-like symptoms
epilepsy
diabetes
liver or kidney disease
bone marrow or blood cell disease
heart disease, low blood pressure
glaucoma
thyroid disease
lupus
brain damage
allergies, especially to other drugs
pregnancy, nursing
breast cancer
surgery
 
 
USE OF THIS DRUG MAY CAUSE OFTEN:
 
severe withdrawal symptoms
strengthening the effects of alcohol
increases effect of other drugs, especially sedatives
Parkinson-like symptoms: shakiness, lack of muscle co-ordination, muscle stiffness
restlessness, sleeplessness
drowsiness
blurred eyesight
dry mouth
constipation
urination problems
confusion, lack of judgement
 
 
SOMETIMES:
 
tardive dyskinesia: uncontrolled movements of the tongue, mouth, arms and legs, which may be permanent and may come after stopping the drug
 
increased psychotic symptoms
changes in mood and behaviour
anxiety, excitement, agitation, restlessness
depression
weakness, being tired, sleeplessness
fever
headache
dizziness, fainting
internal and external spasms
in epileptics: seizures
in the elderly: no thirst sensation, leading to pneumonia
heart problems, heart attack
low white blood cell counts, causing infections
irregular pulse or blood pressure
liver disease
stomach problems, loss of appetite
nausea, vomiting, diarrhea
bloating
skin rash, sensitivity to sun
eye damage
impotence (20%), painful, continuous erection
breast swelling (male and female)
menstrual problems
 
 
RARELY:
 
death, sometimes sudden, from any of these causes: disordered body temperature
bone marrow poisoning
convulsions
blood clots
paralysis of the intestines
cardiac arrest (heart stoppage)
despair leading to suicide
vomiting into lungs*
*(30% of psychiatric patient deaths)
 
 
REMEMBER:
 
 
* This drug should be used only when there is no other choice.
 
 
* Sudden death is a (rare) possibility with Haldol.
 
 
* This is one of a group of psychiatric drugs which causes a serious and sometimes fatal reaction called Neuroleptic Malignant Syndrome. It may cause body temperature raising, rigid muscles and coma (passing out), rapid heart beat and breathing, sweating, shaking and seizures. The death rate is 20%.
 
 
* Haldol causes brain and eye damage with long-term use. With epilepsy, it can change the pattern of seizures.
 
 
* Avoid overheating your body in the sun, saunas, hot baths, etc.


* Tell your nurse, doctor, pharmacist or dentist about any other drugs you are taking before any new treatment. Check with them before you take any medicine, even if it isn't a prescription drug.
 
 
* There is no known treatment for tardive dyskinesia (TD). The brain damage done with this drug can be permanent. If symptoms appear, the drug must be stopped. One of the early signs of TD is a "worm-like" movement of the tongue. Stop the drug and see your doctor immediately if this happens to you. http://consumer.pdr.net/consumer/content/journals/PDRFGWHRX/data/drugs/images/P9 9314E3.JPG


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